Research Article Alternate Warm and Cold Therapy (AWCT) on Uricemia, Sleep, Pain, Functional Ability, and Quality of Life (USPFQoL) in Patients with Gout: A Path Forward Premalatha Paulsamy, 1 Krishnaraju Venkatesan , 2 ShadiaHamoud Alshahrani, 3 Fazil Ahmad, 4 Mohamed El-Sherbiny, 5 Vani Manoharan, 6 Kalaiselvi Periannan, 7 RashaElsayed Ahmed, 8 Kousalya Prabahar, 9 andDawitmamiruteressa 10 1 College of Nursing, Mahalah Branch for Girls King Khalid University, Abha, Asir, Saudi Arabia 2 Department of Pharmacology, College of Pharmacy, King Khalid University, Abha, Asir, Saudi Arabia 3 College of Nursing, Mahalah Branch for Girls, King Khalid University, Abha, Asir, Saudi Arabia 4 DepartmentofAnesthesiaTechnology,CollegeofAppliedMedicalSciencesinJubail,ImamAb-dulrahmanBinFaisalUniversity, P.O. Box 4030, Jubail, Saudi Arabia 5 DepartmentofBasicMedicalSciences,CollegeofMedicine,AlmaarefaUniversity,P.O.Box71666,Riyadh11597,SaudiArabia 6 Georgia CTSA, Emory University Hospital, Atlanta, GA, USA 7 Lecturer in Mental Health Nursing, Oxford School of Nursing & Midwifery, Faculty of Health and Life Sciences, Oxford OX3 0FL, UK 8 Medical Surgical Nursing, College of Nursing Tanta University, Egypt and College of Nursing, Mahalah Branch for Girls King Khalid University, Asir, Saudi Arabia 9 Department of Pharmacy Practice, Faculty of Pharmacy, University of Tabuk, Tabuk 71491, Saudi Arabia 10 Department of Chemical Engineering, College of Biological and Chemical Engineering, Addis Ababa Science and Technology University, Addis Ababa, Ethiopia Correspondence should be addressed to Krishnaraju Venkatesan; kvenkatesan@kku.edu.sa and Dawit mamiru teressa; dawit.mamiru@aastustudent.edu.et Received 11 January 2022; Accepted 8 February 2022; Published 9 March 2022 Academic Editor: Enas Abdulhay Copyright © 2022 Premalatha Paulsamy et al. is is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Objective. To understand the impact of alternate warm and cold therapy (AWCT) on uricemia, sleep, pain, functional ability, and quality of life in gout patients. Methods. A quasiexperimental, nonequivalent control group, pre and posttest design was adopted among 120 gout patients. e data were collected on demographics, comorbidities, pain level, joint swelling/joint tenderness, patient global assessment of response to treatment (PGART), health-related quality of life (HRQoL) with SF-36, sleep quality by Pittsburgh Sleep Quality Index (PSQI), and serum uric acid and assessed. Descriptive and inferential statistics were used to analyze the data. Results. Patients had mean age of 58 and 61 years, mean number of comorbidities was 1.8 and 1.4, as well as presence of arthritic comorbidities except gout was 1.1 and 0.8 among study and control group participants, respectively. Pain (p < 0.001), PGART (p �−0.01), HRQoL, sleep quality, and level of SUA (mg/dl) improved significantly (p < 0.01) among the study group over study periods. It affirms that the AWCT is effective in reducing pain, functional disability, and SUA, as well as improving the sleep quality and HRQoL of the gout patients. ere was a reduced incidence of gout flares (p < 0.001), and taking additional medicines for pain (p < 0.01) was statistically significant among study participants. Except social functioning, other domains of health were significantly (p < 0.05) affected by the comorbidities like hypertension, diabetes, heart disease, renal disease, and asthma/chronic obstructive pulmonary disease. Conclusions. Gout is independently associated with higher medical and arthritic comorbidity, and AWCTcan be better and cost-effective alternative therapy for gout patients. In addition, it may lead to improved cardiac function, hypertension, and renal insufficiency. Hindawi Journal of Healthcare Engineering Volume 2022, Article ID 5471575, 8 pages https://doi.org/10.1155/2022/5471575