This article is protected by copyright. All rights reserved 1 Research Article Mutation in the A-Determinant of the S Gene of the Hepatitis B Virus Associated With Concomitant HBsAg and anti-HBs in a Population in Northeastern Brazil † Ingrid de Campos Albuquerque 1 *, Marinilde Teles Sousa 1 , Max Diego Cruz Santos 2 , Jomar Diogo Costa Nunes 1 , Maria Josélia Diniz Moraes 3 , Michele Soares Gomes-Gouvêa 2 , João Renato Rebelo Pinho 2 , Flair José Carrilho 2 , Lena Maria Barros Fonseca 4 , Adalgisa de Sousa Paiva Ferreira 5 1 Graduate Program of Health Sciences, Federal University of Maranhão, Maranhão, Brazil. 2 Department of Gastroenterology, University of Sao Paulo School of Medicine, São Paulo, Brazil. 3 Maranhão Clinical Research Center, University Hospital of the Federal University of Maranhão, Maranhão, Brazil. 4 Department of Nursing, Federal University of Maranhão, Maranhão, Brazil. 5 Department of Medicine, Federal University of Maranhão, Maranhão, Brazil. * Correspondence to: Ingrid de Campos Albuquerque, Federal University of Maranhão, Maranhão, Brazil. Address: Rua Almirante Tamandaré, 01 Centro 65.020-600 São Luís – Maranhão. Fone: (98) 2109-1293 email: ingrid.c.albuquerque@gmail.com † This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: [10.1002/jmv.24653] Received 5 April 2016; Revised 28 July 2016; Accepted 29 July 2016 Journal of Medical Virology This article is protected by copyright. All rights reserved DOI 10.1002/jmv.24653