Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved. Abstracts e97 Women with increased UA had 254% increased odds (adjusted OR = 2.54, p = 0.005) to be classified in the upper range of the DD score. Conclusions: In asymptomatic hypertensive subjects, UA is independently as- sociated with the presence of DD in both genders and correlates with its severity in women. Further prospective studies are warranted to evaluate the association of UA with adverse cardiovascular outcomes in high risk populations such as HF with pEF. PP.01.14 URIC ACID AS A PREDICTOR OF CORONARY ARTERY DISEASE BUT NOT STROKE IN ESSENTIAL HYPERTENSION: DATA FROM A GREEK 8-YEAR- FOLLOW-UP STUDY K. Dimitriadis, C. Tsioufis, A. Kasiakogias, G. Georgiopoulos, T. Kalos, K. Kyriazopoulos, G. Annousis, E. Andrikou, D. Tousoulis. First Cardiology Clin- ic, University of Athens, Hippokration Hospital, Athens, Greece Objective: The exact role of uric acid in cardiovascular risk prediction remains to be further determined. The aim of the present study was to assess the predictive role of uric acid for the incidence of coronary artery disease (CAD) as well as stroke in essential hypertensive patients. Design and method: We followed up 2415 essential hypertensives (mean age 58.4 years, 1208 males, office blood pressure (BP) = 143/88 mmHg) for a mean period of 8 years. All subjects had at least one annual visit and at baseline under- went echocardiographic study and blood sampling. Moreover, CAD was defined as the history of myocardial infarction or significant coronary artery stenosis and stroke was defined as rapid onset of a new neurological deficit persisting at least 24 hours unless death supervened confirmed by imaging findings. Results: The incidence of CAD and stroke was 2.2% and 1% respectively. Hy- pertensives who developed CAD (n = 53) compared to those without CAD at follow-up (n = 2362) had at baseline higher baseline uric acid levels (5.8 ± 1.8 vs 5.2 ± 1.5 mg/dl, p = 0.011), left ventricular mass index (LVMI) (115.7 ± 27.1 vs 103.7 ± 27.1 g/m 2 , p = 0.001) and prevalence of LV hypertrophy (41% vs 25%, p = 0.017) whereas no difference was observed with respect to baseline office BP, renal function and lipid levels (p = NS for all). Hypertensives who developed stroke (n = 24) compared to those without CAD at follow-up (n = 2391) were older (63 ± 8 vs 58 ± 11 years, p = 0.006) whereas no difference was observed with respect to baseline office BP, uric acid, renal function and lipid levels (p = NS for all). Univariate Cox regression analysis revealed that baseline uric acid levels predicted CAD (hazard ratio = 1.219, p = 0.013) but not stroke. In multivariate Cox regression model baseline glomerular filtration rate (hazard ratio = 1.018, p = 0.017) LVMI (hazard ratio = 1.010, p = 0.026) and uric acid (hazard ra- tio = 1.226, p = 0.016) turned out to be independent predictors of CAD, while age (hazard ratio = 1.058, p = 0.014) predicted stroke. Conclusions: In essential hypertensive patients uric acid predicts future develop- ment of CAD, whereas exhibits no prognostic value for stroke. These findings further support that uric acid estimation could improve overall risk stratification in essential hypertension. PP.01.15 SYSTOLIC ARTERIAL HYPERTENSION IN UKRAINE: REALITIES OF CLINICAL PRACTICE BASED ON TRIAL SYSTEM V. Tseluyko. Kharkiv medical academy of postgraduate education, Kharkiv, Ukraine Objective: The aim of this trial was to evaluate efficacy of SBP control among hypertensive patients in Ukraine based on data of the register of patients. Design and method: The register included patients who visited cardiologist in the period from 28 Oct 2015 to 15 DEC 2015. 148 doctors from 11 regions of Ukraine was involved in the creation of this register during the trial. Results: 2964 patients (1627 (54,9%) women) aged 19 to 90 years (60,6 ± 11,5 years) were included in the register. Results of office BP analysis indicate bad control of BP (average DBP 94,2 mm Hg, SBP – 164,5 mm Hg). Less than 7% of analyzed patients had target BP. Results of analysis indicate the relation between the level of SBP and DBP and age. Correlation analysis was performed for evaluation the relation between the levels of SBP and DBP and age. Results of analysis indicate the positive relation between age and SBP (rho = 0,149, p < 0,001) and negative - between age and DBP (rho = –0,158, p < 0,001). It was found the relation between the level of SBP and target-organs damage - LVH, CKD. Conclusions: Analysis of results of the register indicates bad control of BP especially SBP in Ukraine. Only 7% of patients achieve target BP. The level of SBP increases with age and is associated with increasing of frequency of target-organs damages. PP.01.17 ADDING HYPERTENSION-RELATED MARKERS OF ORGAN DAMAGE TO RISK SCORE MODELS IMPROVES CARDIOVASCULAR RISK ASSESSMENT: RETROSPECTIVE ANALYSIS OF A LARGE COHORT OF ADULT OUTPATIENTS G. Tocci 1,2 , I. Figliuzzi 1 , V. Presta 1 , G. Gallo 1 , V. Costanzi 1 , N. Attalla 1 , F. Simonelli 1 , B. Citoni 1 , A. Battistoni 1 , A. Ferrucci 1 , M. Volpe 1,2 . 1 Div. Cardi- ology, Dpt. Clinical Molecular Medicine, Fac. Medicine and Psychology, Univ. Sapienza, Sant’Andrea Hospital, Rome, Italy, 2 IRCCS Neuromed, Pozzilli, Italy Objective: Global cardiovascular (CV) risk stratification is currently recom- mended in all adult outpatients in both primary and secondary prevention. Avail- able risk score charts, however, do not include markers of organ damage (OD). Design and method: Aim. To evaluate potential value of adding different mark- ers of hypertension-related subclinical OD to US Framingham, European SCORE and Italian Cuore risk score calculators. Methods: We retrospectically evaluated adult hypertensive outpatients, who un- derwent blood pressure (BP) assessment and global CV risk stratification at our Hypertension Unit. The following definitions were applied: 1) cardiac OD: elec- trocardiographic (Sokolow–Lyon index: >3.5 mV; Cornell Voltage Index: men >2.4 mV; women >2.0 mV) or echocardiographic left ventricular (LV) hypertro- phy (LV mass index: men >115 g/m 2 ; women >95 g/m 2 ); 2) vascular OD: carotid atherosclerotic plaque (>1,5 mm); 3) renal OD: reduced estimated glomerular filtration rate (eGFR < 60 ml/min/1.73m 2 ) or clearance creatinine (ClCr < 60 ml/ min). Different risk score calculators were applied to all included patients. Results: We included an overall population sample of 1,979 adult outpatients (44.0% female, age 57.2 ± 13.0 years, BMI 26,6 ± 4,4 kg/m 2 , clinic systolic/diastolic BP 145.4 ± 18.3/85.8 ± 10.7 mmHg), among whom 117 (5.9%) had cardiac, 161 (8.1%) vascular, and 117 (5.9%) renal OD, respectively. US Framingham, Euro- pean SCORE and Italian Cuore risk scores were all significantly higher in patients with than in those without OD, independently by type and number of OD, as well as age and gender classes. In particular, direct comparisons for US Framingham CVD death, European ESC score and Italian Cuore score showed significantly higher risk in those patients with both ECG-detected LV hypertrophy, ECHO- detected LV hypertrophy, carotid atherosclerosis and reduced eGFR (Figure 4a) or ClCr than in those without the corresponding markers of OD. Conclusions: Presence of cardiac, vascular or renal OD is associated with higher risk scores, independently by type of calculators, age and gender classes. OD de- tection should be included in individual CV risk stratification aimed at improving diagnostic and therapeutic process. PP.01.18 ARE WE LOOKING IN THE RIGHT DIRECTION FOR BLOOD PRESSURE CONTROL? I. Tilea 1 , A. Varga 1 S.I. Morar 2 , C.M. Tatar 3 , A.E. Bocicor 1 . 1 Family Medicine, Faculty of Medicine, University of Medicine and Pharmacy, Targu Mures, Romania, 2 Internal Medicine Clinic III, Emergency Clinical County Hospital, Targu Mures, Romania, 3 Internal Medicine III, Faculty of Medicine, University of Medicine and Pharmacy, Targu Mures, Romania Objective: The efficiency of antihypertensive treatment of free versus fixed com- bination and blood pressure control was assessed together with the number of antihypertensive classes used for on target blood pressure (BP) control in real life practice of adult population. Design and method: An observational retrospective study was performed on a cohort of 484 adult hypertensive patients (mean age 62.06 ± 12.30 y.o.) from an