279 Matin et al. Int. J. Biosci. 2013 RESEARCH PAPER OPEN ACCESS Synthesis and comparative antimicrobial studies of some acylated D-glucofuranose and D-glucopyranose derivatives Mohammed M. Matin 1* , M.M.H. Bhuiyan 1 , Dulal C. Debnath 1 , M.A. Manchur 2 1 Organic Research Laboratory, Department of Chemistry, University of Chittagong, Chittagong- 4331, Bangladesh 2 Department of Microbiology, University of Chittagong, Chittagong-4331, Bangladesh Key words: Glucofuranose, glucopyranose, antimicrobial activity, structure activity relationship (SAR). doi: http://dx.doi.org/10.12692/ijb/3.8.279-287 Article published on August 22, 2013 Abstract Some acylated D-glucofuranose (2, 3, 5, 6) and D-glucopyranose (8, 9) derivatives were prepared by direct acylation method for comparative antimicrobial studies. All the compounds (1-9) were screened for in vitro antibacterial activity against ten human pathogenic bacteria and antifungal activity against four pathogenic fungi. The study revealed that the D-glucopyranose derivatives were more prone towards antimicrobial functionality than that of the D-glucofuranose derivatives. * Corresponding Author: Mohammed M. Matin  mmmatin2004@yahoo.co.in International Journal of Biosciences | IJB | ISSN: 2220-6655 (Print) 2222-5234 (Online) http://www.innspub.net Vol. 3, No. 8, p. 279-287, 2013