How to Cite: Kumar, G. K., Goudanavar, P., Acharya, A., & Ramesh B, R. B. (2022). Passive and iontophoretic delivery of bifonazole loaded Liposomal formulation: A comparative study . International Journal of Health Sciences, 6(S7), 2559–2571. https://doi.org/10.53730/ijhs.v6nS7.11910 International Journal of Health Sciences ISSN 2550-6978 E-ISSN 2550-696X © 2022. Manuscript submitted: 9 April 2022, Manuscript revised: 18 June 2022, Accepted for publication: 27 July 2022 2559 Passive and iontophoretic delivery of bifonazole loaded Liposomal formulation: A comparative study G.B Kiran Kumar* Department , of Pharmaceutics, Sri Adichunchanagiri College of Pharmacy, B.G. Nagara-571448, Karnataka, India *Corresponding Author email: gbkk330@gmail.com Prakash Goudanavar Dept. of Pharmaceutics, Sri Adichunchanagiri College of Pharmacy, B.G. Nagara- 571448, Karnataka, India Ankit Acharya Dept. of Pharmaceutics, Sri Adichunchanagiri College of Pharmacy, B.G. Nagara- 571448, Karnataka, India Ramesh B Dept. of Pharmaceutics, Sri Adichunchanagiri College of Pharmacy, B.G. Nagara- 571448, Karnataka, India Abstract---Fungal infections are one of the most common dermatological conditions worldwide. The goal of this study was to create and test a liposomal version of the antifungal medication Bifonazole. The thin film approach was used to make nine batches of Bifonazole liposomal gel, each with a different ratio of cholesterol, soya lecithin, and stearyl amine. It was investigated how formulation variables affected entrapment efficiency, particle size, surface charge, and drug release behaviour. The addition of a positively charged surfactant like stearyl amine improves the entrapment effectiveness of Bifonazole into liposomes considerably. When compared to the other formulations, the LFG8 formulation had the highest drug-loading capacity (83.210.69%). After 24 hours, the total amount of medication released from the Bifonazole liposomal gel ranged from 51.520.67% to 83.210.69%. The molar ratio of soya lecithin in the formulation rose, delaying drug release. This may be due to Bifonazole's interaction with the vast surface area of the liposome's lipid bilayer membrane and the thickness and fluidity of the soya lecithin layer. In an ex-vivo skin permeation investigation, it was discovered that iontophoretic administration had superior penetration than passive diffusion. Iontophoresis dramatically enhances the amount of medication that is