How to Cite: Sarwoko, S., Agusman, F., & Nurhayati, S. (2022). The role of religious coping in quality of life among people with chronic disease: A systematic review. International Journal of Health Sciences, 6(S4), 6352–6363. https://doi.org/10.53730/ijhs.v6nS4.9590 International Journal of Health Sciences ISSN 2550-6978 E-ISSN 2550-696X © 2022. Manuscript submitted: 27 March 2022, Manuscript revised: 9 May 2022, Accepted for publication: 18 June 2022 6352 The role of religious coping in quality of life among people with chronic disease: A systematic review Sarwoko School of Health Estu Utomo, Boyolali, Central Java, Indonesia Corresponding author email: sikoeub@gmail.com Fery Agusman Master of Nursing Karya Husada University, Semarang, Central Java, Indonesia Susi Nurhayati Master of Nursing Karya Husada University, Semarang, Central Java, Indonesia Abstract---This study aims to assess the association of religious coping and social support and self-care toward general quality of life among people with chronic disease. This article was a systematic review study conducted by searching primary articles from online databases including Google Scholar, PubMed, and Science Direct. We systematically searched full articles with the publication year until 2022. Results: Ultimately, 9 studies met the inclusion criteria of the present study and were included in the review. We completed a quality assessment using the Newcastle–Ottawa Quality Assessment scales for observational studies. We found that there was a positive association between positive religious coping with quality of life and hope among patients with cancer or diabetes type 2. We also found that positive religious coping can affect physical symptoms, adjustment to cancer, adherence to treatment, and reducing depression. Conclusion: Positive religious coping can affect the quality of life among patients with chronic diseases, such as cancer and diabetes type 2. Keywords---coping, religious, cancer, diabetes mellitus, diabetes type 2, quality of life. Introduction The Centers for Disease Control and Prevention (CDC) define chronic diseases as conditions that last 1 year or more and that require ongoing medical attention or