Journal Pre-proof Docking interactions determine early cleavage events in insulin proteolysis by pepsin: Experiment and simulation Michał Koliński, Sebastian Kmiecik, Robert Dec, Marcin Piejko, Paweł Mak, Wojciech Dzwolak PII: S0141-8130(19)40190-6 DOI: https://doi.org/10.1016/j.ijbiomac.2020.01.253 Reference: BIOMAC 14558 To appear in: International Journal of Biological Macromolecules Received date: 10 December 2019 Revised date: 20 January 2020 Accepted date: 25 January 2020 Please cite this article as: M. Koliński, S. Kmiecik, R. Dec, et al., Docking interactions determine early cleavage events in insulin proteolysis by pepsin: Experiment and simulation, International Journal of Biological Macromolecules(2018), https://doi.org/ 10.1016/j.ijbiomac.2020.01.253 This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. © 2018 Published by Elsevier.