226 Int. J. Information Systems and Change Management, Vol. 4, No. 3, 2010 Copyright © 2010 Inderscience Enterprises Ltd. Information systems and change management in healthcare: the (un)solved quest for changing physicians’ behaviour Emanuele Lettieri*, Giovanni Radaelli and Cristina Masella Department of Management, Economics and Industrial Engineering, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milano, Italy Fax: +39 02 2399 4083 E-mail: emanuele.lettieri@polimi.it E-mail: giovanni.radaelli@polimi.it E-mail: cristina.masella@polimi.it *Corresponding author Abstract: This paper identifies 19 factors that affect physicians’ behavioural changes due to the adoption of new clinical information systems and ten interventions that hospital managers can introduce to facilitate change management. Despite information systems have been acknowledged as major enablers of performance improvement in healthcare delivery, numerous failures to adopt and implement are documented in the literature. The authors carried out a systematic literature review to identify factors and interventions that can facilitate or inhibit physicians’ behavioural changes. Selected factors have been synthesised assuming the theory of planned behaviour (TPB) as main theoretical framework. Relationships between factors and interventions have been reviewed and discussed. Keywords: information systems; change management; clinical decision support systems; CDSSs; theory of planned behaviour; TPB; physicians’ acceptance; healthcare. Reference to this paper should be made as follows: Lettieri, E., Radaelli, G. and Masella, C. (2010) ‘Information systems and change management in healthcare: the (un)solved quest for changing physicians’ behaviour’, Int. J. Information Systems and Change Management, Vol. 4, No. 3, pp.226–245. Biographical notes: Emanuele Lettieri is an Assistant Professor at the Department of Management, Economics and Industrial Engineering at Politecnico di Milano. His research activities are mainly related to technology assessment and management of technology, with a focus to healthcare. He is the co-author of various publications in those research fields. He is the Lecturer of Economics and Business Administration and he has been involved in various projects related to performance improvement and change management in healthcare organisations. At present, he is collaborating an EU funded project aimed at developing a clinical decision support system for risk management in hospitals. Giovanni Radaelli is a PhD student at the Department of Management, Economics and Industrial Engineering at Politecnico di Milano. His main interest concerns the mechanisms of adoption and institutionalisation of ICT