SPINAL NEURORADIOLOGY Effects of age and sex on the distribution and symmetry of lumbar spinal and neural foraminal stenosis: a natural language processing analysis of 43,255 lumbar MRI reports Michael Travis Caton Jr 1,2 & Walter F. Wiggins 1,3 & Stuart R. Pomerantz 4 & Katherine P. Andriole 1,5 Received: 16 November 2020 /Accepted: 3 February 2021 # The Author(s) 2021 Abstract Purpose The purpose of this study is to investigate relationship of patient age and sex to patterns of degenerative spinal stenosis on lumbar MRI (LMRI), rated as moderate or greater by a spine radiologist, using natural language processing (NLP) tools. Methods In this retrospective, IRB-approved study, LMRI reports acquired from 2007 to 2017 at a single institution were parsed with a rules-based natural language processing (NLP) algorithm for free-text descriptors of spinal canal stenosis (SCS) and neural foraminal stenosis (NFS) at each of six spinal levels (T12-S1) and categorized according to a 6-point grading scale. Demographic differences in the anatomic distribution of moderate (grade 3) or greater SCS and NFS were calculated by sex, and age and within-group differences for NFS symmetry (left vs. right) were calculated as odds ratios. Results Forty-three thousand two hundred fifty-five LMRI reports (34,947 unique patients, mean age = 54.7; sex = 54.9% women) interpreted by 152 radiologists were studied. Prevalence of significant SCS and NFS increased caudally from T12-L1 to L4-5 though less at L5-S1. NFS was asymmetrically more prevalent on the left at L2-L3 and L5-S1 (p < 0.001). SCS and NFS were more prevalent in men and SCS increased with age at all levels, but the effect size of age was largest at T12-L3. Younger patients (< 50 years) had relatively higher NFS prevalence at L5-S1. Conclusion NLP can identify patterns of lumbar spine degeneration through analysis of a large corpus of radiologist interpreta- tions. Demographic differences in stenosis prevalence shed light on the natural history and pathogenesis of LSDD. Keywords Spinal stenosis . MRI . Neuroradiology . Lumbar spine . Natural language processing . Neural foramen . Degenerative disease Abbreviations LMRI Lumbar spine MRI SCS Spinal canal stenosis NFS Neural foraminal stenosis LSDD Lumbar spine degenerative disease NLP Natural language processing TLSA Transitional lumbosacral anatomy () A portion of this material was presented orally at the Society for Imaging Informatics (SIIM) Annual Meeting 2019. The material herein has not been published in part or in whole. * Michael Travis Caton, Jr Michael.caton2@ucsf.edu; travis.caton@gmail.com Walter F. Wiggins walter.f.wiggins@gmail.com Stuart R. Pomerantz spomerantz@mgh.harvard.edu Katherine P. Andriole kandriole@bwh.harvard.edu 1 Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA 2 Present address: University of California San Francisco, 505 Parnassus Avenue, L352, CA 94117 San Francisco, USA 3 Present address: Duke University, Durham, NC, USA 4 Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA 5 MGH and BWH Center for Clinical Data Science, Boston, MA, USA https://doi.org/10.1007/s00234-021-02670-6 / Published online: 16 February 2021 Neuroradiology (2021) 63:959–966