ﻣﻮاد ﭘﯿﺸﺮﻓﺘﻪ در ﻣﻬﻨﺪﺳﯽ، ﺳﺎل38 ، ﺷﻤﺎرة3 ، ﭘﺎﯾﯿﺰ1398 87 ﺗ ﺄ ﺛﯿﺮ ﻋﻨﺼﺮ ﻣﺲ ﺑﺮ ﻧﺮخ ﺗﺨﺮﯾﺐ و ﺧﻮاص ﺑﯿﻮﻟﻮژﯾﮑﯽ آﻟﯿﺎژ ﻣﻨﯿﺰﯾﻢ- آﻟﻮﻣﯿﻨﯿﻮم- ﻣﺲ ﺳﺎﺧﺘﻪ ﺷﺪه ﺑﻪ روش ﭘﻼﺳﻤﺎي ﺟﺮﻗﻪ اي ﻧﺮﮔﺲ ﺻﻔﺮي 1 * ، ﻣﺤﻤﺪرﺿﺎ ﻃﺮﻗﯽ ﻧﮋاد 1 ، ﻣﻬﺸﯿﺪ ﺧﺮازﯾﻬﺎ 1 و وﺣﯿﺪه ﺳﻌﯿﺪي 2 1 . داﻧﺸﮑﺪه ﻣﻬﻨﺪﺳﯽ ﻣﻮاد، داﻧﺸﮕﺎه ﺻﻨﻌﺘﯽ اﺻﻔﻬﺎن 2 . داﻧﺸﮑﺪه ﻣﻬﻨﺪﺳﯽ ﮐﺸﺎورزي ، داﻧﺸﮕﺎه ﺻﻨﻌﺘﯽ اﺻﻔﻬﺎن درﯾﺎﻓﺖ ﻣﻘﺎﻟﻪ:) 29 / 3 / 1398 - درﯾﺎﻓﺖ ﻧﺴﺨﻪ ﻧﻬﺎﯾﯽ:6 / 6 / 1398 ( DOI: 10.29252/jame.36.3.1 ﭼﮑﯿﺪه- ﻫﺪف از اﻧﺠﺎم اﯾﻦ ﭘﮋوﻫﺶ، ﺳﺎﺧﺖ آﻟﯿﺎژﻫﺎيMg-Al-Cu ) ﺣﺎوي ﻣﻘﺎدﯾﺮ ﻣﺨﺘﻠﻒ ﻣﺲ0 ، 25 / 0 ، 5 / 0 و1 درﺻﺪ ﺑﻪ( وزﻧﯽ ﮐﻤـﮏ روش ﺗﻒ ﺟﻮﺷﯽ ﺟﺮﻗﻪ اي و ارزﯾﺎﺑﯽ ﻧﺮخ ﺗﺨﺮﯾﺐ و ﺧﻮاص ﺑﯿﻮﻟﻮژﯾﮑﯽ آﻧﻬﺎ اﺳﺖ. ﻧﺘﺎﯾﺞ ﻧﺸﺎن داد ﮐﻪ ﺑـﺎ اﻓـﺰودن25 / 0 درﺻـﺪ ﻣـﺲ ﻧـﺮخ ﺗﺨﺮﯾﺐ از039 / 0 ﺳﺎﻧﺘﯽ ﻣﺘﺮ ﺑﺮ ﺳﺎﻋﺖ در ﻣﻨﯿﺰﯾﻢ ﺧﺎﻟﺺ ﺑﻪ0058 / 0 ﺳﺎﻧﺘﯽ ﻣﺘﺮ ﺑﺮ ﺳﺎﻋﺖ ﮐﺎﻫﺶ ﯾﺎﻓﺖ. ﺑﻪ ﻋﻼوه درﺻﺪ زﯾﺴﺖ ﭘـﺬﯾﺮي ﺳـﻠﻮل ﻫﺎيMG63 در ﺗ ﻤﺎس ﺑﺎ آﻟﯿﺎژMg-1Al-0.25Cu ﺑﻪ ﻃﻮر ﻗﺎﺑﻞ ﺗﻮﺟﻬﯽ) ﺑﺎﻻﺗﺮ25 / 1 ( ﺑﺮاﺑﺮ از آن در ﺗﻤﺎس ﺑﺎ ﻣﻨﯿﺰﯾﻢ ﺧﺎﻟﺺ ﺑﻮد ﮐﻪ ﺑﻪ دﻟﯿﻞ ﻧﺮخ ﻣﻨﺎﺳﺐ رﻫﺎﯾﺶ ﯾﻮن ﻋﻨﺎﺻﺮ ﺑﻮد. ﻫﻤﭽﻨﯿﻦ، آﻟﯿﺎژMg-1Al-0.25Cu ﻣﺲ رﻓﺘﺎر ﺿﺪﺑﺎﮐﺘﺮﯾﺎﯾﯽ ﻗﺎﺑﻞ ﺗﻮﺟﻬﯽ از ﺧﻮد ﻧﺸﺎن داد. ﺑﻨﺎﺑﺮاﯾﻦ آﻟﯿﺎژMg- 1Al-0.25Cu ﺑﺎ ﻧﺮخ ﺗﺨﺮ ﯾﺐ ﻣﻨﺎﺳﺐ، زﯾﺴﺖ ﺳﺎزﮔﺎري ﻣﻄﻠﻮب و ﺧﻮاص ﺿﺪﺑﺎﮐﺘﺮﯾﺎﯾﯽ ﻣﯽ ﺗﻮاﻧﺪ ﺑﻪ ﻋﻨﻮان ﮐﺎﺷﺘﻨﯽ ارﺗﻮﭘﺪي زﯾﺴﺖ ﺗﺨﺮﯾﺐ ﭘﺬﯾﺮ ﻣﻌﺮﻓﯽ ﺷﻮد. واژه ﻫﺎ ي ﮐﻠ ﯿ ﺪ ي: آﻟﯿﺎژﻫﺎي ﻣﻨﯿﺰﯾﻢ، ﻧﺮخ ﺗﺨﺮﯾﺐ، ﺳﻤﯿﺖ ﺳﻠﻮﻟﯽ، ﺧﻮاص آﻧﺘﯽ ﺑﺎﮐﺘﺮﯾﺎل. Influence of Cu Element on Degradation Rate and Biological Properties of Mg-Al-Cu Alloy Prepared by Spark Plasma Sintering N. Safari 1* , M. Toroghinejad 1 , M. Kharaziha 1 and V. Saeedi 2 1. Department of Materials Engineering, Isfahan University of Technology, Isfahan, Iran. 2. Department of Agricultural Engineering, Isfahan University of Technology, Isfahan, Iran. Abstract: The aim of this study was to fabricate the Mg-1Al-Cu alloys with various amounts of Cu content (0, 0.25, 0.5 and 1 wt.%) using spark plasma sintering (SPS) approach and evaluation of their degradation rate and biological properties. The results indicated that Cu incorporation (0.25 wt.%) significantly diminish degradation rate from 0.039 cm/h in pure Mg to 0.00584 cm/h in Mg-1Al-0.25Cu alloy. In addition, Mg-1Al-0.25Cu alloy could noticeably (1.25 times) promote viability of MG63 cells compared to pure Mg, owing to the optimized ion release. Moreover, the antibacterial activity of Mg-1Al-0.25Cu was considerable. In summary, Mg-1Al-0.25Cu alloy with appropriate degradation rate, good biocompatibility and antibacterial properties can be introduced as a biodegradable orthopedic implant. * : ﻣﺴﺌﻮل ﻣﮑﺎﺗﺒﺎت، ﭘﺴﺖ اﻟﮑﺘﺮوﻧﯿﮑﯽ:Ngs.Safari1991@gmail.com Downloaded from jame.iut.ac.ir at 22:05 IRST on Thursday December 2nd 2021 [ DOI: 10.47176/jame.38.3.20931 ]