Shukla et al Journal of Drug Delivery & Therapeutics. 2022; 12(4-S):264-269 ISSN: 2250-1177 [264] CODEN (USA): JDDTAO Available online on 25.08.2022 at http://jddtonline.info Journal of Drug Delivery and Therapeutics Open Access to Pharmaceutical and Medical Research Copyright © 2011-2022 The Author(s): This is an open-access article distributed under the terms of the CC BY-NC 4.0 which permits unrestricted use, distribution, and reproduction in any medium for non-commercial use provided the original author and source are credited Open Access Full Text Article Review Article Floating Microsponge: An Emerging Drug Delivery System Mukesh Kumar Shukla 1 , Abadhesh Kumar Niranjan* 2 1 Research Scholar, Department of Pharmaceutics, Hygia Institute of Pharmaceutical Education and Research, Lucknow (U.P.) 226020, India 2 Associate Professor, Department of Pharmaceutics, Hygia Institute of Pharmaceutical Education and Research, Lucknow (U.P.) 226020, India Article Info: _____________________________________________ Article History: Received 22 June 2022 Reviewed 13 August 2022 Accepted 21 August 2022 Published 25 August 2022 _____________________________________________ Cite this article as: Shukla MK, Niranjan AK, Floating Microsponge: An Emerging Drug Delivery System, Journal of Drug Delivery and Therapeutics. 2022; 12(4- S):264-269 DOI: http://dx.doi.org/10.22270/jddt.v12i4-s.5553 _____________________________________________ *Address for Correspondence: Abadhesh Kumar Niranjan, Associate Professor, Department of Pharmaceutics, Hygia Institute of Pharmaceutical Education and Research, Lucknow (U.P.) 226020, India Abstract ___________________________________________________________________________________________________________________ Floating microsponges are a method to extend gastric residence time, there with the aid of using concentrated on site-responsive medicament liberate withinside the top GIT for locally or systemic effect. Gastro retentive dosage forms (GRDFs) are getting utilized from a totally long term to enhance treatment with numerous main medications. Floating microsponge significantly enhances the therapy of stomach with the aid of using liberating the medication locally and for that reason used for medication selecting at specific organ. This may be sustained over an extended period of time. Floating drug delivery allow extended and non-stop release of the drug to the top a part of Gastro intestinal tract and this expressively amplify the period of drug release and enhance pharmacokinetic of medication which have slim healing window, with the aid of using this method dosing frequency and affected person compliance is increased. A microsponge’s drug delivery system is a particularly cross-linkage, spongy, polymeric microsphere, polymeric device consisting permeable microspheres. Microsponges are prepared with the aid of using numerous techniques consisting of liquid-liquid suspension polymerization and quasi emulsion solvent diffusion method. Microsponge,s preparations are strong over variety of pH 1 to 11; microsponge,s preparations are strong on the temperature as much as 130 0 C well suited with maximum vehicles and ingredients. The present assessment introduces microsponge,s technology at the side of its techniques of preparation, characterization, advantages, evaluation and release mechanism of microsponge,s drug delivery system, advertised product and up to date studies regarding microsponge. Keywords: Floating microsponge, Oral administration, Controlled release, Quasi emulsion, Target release. Contact No. 8317008539 E-mail: niranjanpharma88@gmail.com 1. Introduction: 1.1 Floating Drug Delivery System [FDDS]: 1,2,3 Oral route is maximum ideally path of drug delivery to easy administration, pliability in preparation, low price and affected person compliance. Oral controlled release drug delivery system suggests a few restrictions associated with gastric emptying time. Too rapid and variable gastric emptying should results in insufficient drug release from dosage form into absorption window main to low effectiveness of administered dose. Floating drug delivery system become to put together the presently awareness at the principle procedure of ability to float to acquire gastric retention time. The modern tendencies of FDDS together with the biological and approach variables influencing gastric retention, strategies to format floating structure, and their class and approach elements are enclosed in detail. Gastroretentive system can remain within the gastric region for several hours and as a result appreciably extend gastric residence time of drug. Prolong gastric retention enhances pliability of drugs which might be much less soluble in an immoderate pH environment}, decreases drug wastages and enhance bioavailability. FDDS has the main utility for the delivery of local drugs to the stomach. 1.2 Basic Gastrointestinal tract Physiology: 4 For the improvement of Gastro-retentive drug delivery method should have expertise of body structure of gastrointestinal tract. Anatomically the stomach is split into 3 parts- (1) fundus, (2) body and (3) antrum(pylorus) The contiguous element fabricated from fundus and undigested material store in frame so frame acts as reservoir, and antrum (pylorus) is the responsible web page for mixing motion and acts as a pump, cause gastric emptying. Stomach Physiology: 2,4 The maximum crucial function of stomach is to process and to convey the food. It act as a short‐time period storage reservoir, enzymatic digestion started out in stomach wherein various juices mix with food which is probably produced via gastric smooth muscles and ensuing in liquefaction of food and it's miles released for small intestine for in addition process]. Stomach is part of digestive system that's located amongst oesophagus and small bowel. Structurally the wall of stomach is alike to the alternative components of the digestive tube but stomach has a likewise oblique layer of smooth muscle inside the spherical layer which permits the motion inside the stomach. When stomach is empty, it's far gotten smaller and its mucous membrane and sub mucous membranes are thrown up into wonderful folds known as rugae.