DEVELOPMENT AND EVALUATION OF GASTRO RETENTIVE FLOATING MICROSPONGE DRUG DELIVERY SYSTEM CONTAINING PSIDIUM GUAJAVA LEAVES EXTRACT Mukesh Kumar Shukla, Abadhesh Kumar Niranjan* Hygia Institute of Pharmaceutical Education and Research, Sitapur- Hardoi Bypass Road, Opp. Sahara City Homes, PrabandhNagar, Lucknow, Uttar Pradesh, India 226013, Corresponding author: Abadhesh Kumar Niranjan Corresponding Email:niranjanpharma88@gmail.com ABSTRACT The FDDS can reduce drug plasma level fluctuations and lead to fewer side effects, more frequent dosage, and better patient compliance. The absorbance maxima (max) of Psidium guajava leaves extract in 0.1 N HCl solution were reported to be at 266 nm. Excellent linearity of the data is demonstrated by the calibration curves, as indicated by correlation coefficient values greater than 0.99. Eight gastro-retentive Floating Microsponges compositions of Psidium guajava leaves extract were created in the current study utilizing the quasi-emulsion solvent diffusion method. To normalize the effects on the drug-delivery profile, different amounts of polymers, including Eudragit S-100, polyvinyl alcohol, ethyl cellulose, Dichloromethane, and tween 80, were used. >80% of the medication was released in the target drug release profile within 12 hours. Angle of repose, bulk density, tapped density, compressibility index, Hausner's ratio, particle size determination, floating time, % entrapment efficiency, percentage buoyancy, and invitro drug release are some of the criteria that floating microsponges were assessed for. SEM images were taken of the surface morphology and form of manufactured floating microsponges. The effectiveness of the drug trapping was between 82.52% and 91.43%. The capability of all formulations to float was assessed using the invitro buoyancy% of floating microsponges. For minimum 7 to 12 hours, all of the developed formulations floated. Keywords:Gastro-retention, floating microsponges, Psidium guajava leaves extract, Eudragit S-100, Dichloromethane. 1. INTRODUCTION The oral formulations retention in the upper GI tract increases bioavailability and, as a result, therapeutic effectiveness by extending the duration that the drug is in touch with the GI mucosa. Additionally, it expedites medication administration, may lead to lesser dosages. High Technology Letters Volume 28, Issue 10, 2022 ISSN NO : 1006-6748 http://www.gjstx-e.cn/ 258