International J Effect of Sambiloto (A Cholesterol Levels in Rizky Dzariyani Laili*, Arie Dwi Department of Nutrition, Sekolah Tin Indonesia *Correspondence E-mail : rizkyla Abstract Introduction : The risk of at Flavonoids may help inhibit th levels.Flavonoids are widely ava examine the effect of flavonoids This research was carried out u Wistar rats. Group (K-) received atherogenic diets rats that pre-tr stew. APL stew is orally gavage CHOD-PAP method. Statistical a results showed a significant diffe with other treatment groups (p = g and 2.4 g of APL produce cho inhibit the elevated levels of ser which contributed 54.8%.While fa fat dose intake together affect th The dose that is considered a producescholesterol level closes Keywords: Andrographis panicu Introduction Prevalence of hypercholester women and 30% men in Riskesd 2013. WHO data in 2015 showe worldwide caused by heart disease by 45%. Riskesdas 2 prevalence of heart disease of 1 line with research conducted Registration System Indones showing that the highest caus Indonesia from heart disease is 2019). Int J Adv Life Sci Res https://doi.org/10.31632/ija 26 Journal of Advancement in Life Sciences Rese Online ISSN: 2581-4877 journal homepage http://ijalsr.org Andrographis paniculata) Leaves Wistar Rats with Atherogenic Die i Alristina, Rossa Kurnia Ethasari, Dewinta Ha nggi Ilmu Kesehatan Hang Tuah Surabaya, Jl. Gadung aili@stikeshangtuah-sby.ac.id therosclerosis increases when elevated blood he absorption of fat, which indirectly helps i ailable on the Andrographis paniculata leaves (AP s in APL stewto lower the cholesterol levels. Mat using five different groups of Wistarrats. Each g normal diet, group (K+) received atherogenic die reated with three different doses (0.6, 1.2, and 2 ed for 60 days. The cholesterol blood serum was analysis using One-Way ANOVA and Post-Hoc T erence in cholesterol levels between the groups o 0.000).When compared with thenormal diet grou olesterol levels not significantly different.APLstew rum cholesterol in male Wistar rats that fed with at intake increased the cholesterol level by 16.3% he formation of cholesterol with a contribution of 6 as the most effective in lowering cholesterol st to normal. ulata; atherogenic diet; cholesterol rol is 39.6% das, Indonesia ed that deaths and vascular 2018 shows a 1.5%. This is in d by Sample sia in 2014 se of death in s 12.9% (KKRI Consumption of high-f antioxidants is one of t atherosclerosis. Saturate increase cholesterol leve can help inhibit the abs indirectly help lower (Widjajakusuma et al. 201 At the moment the grou widely used is the group with muscle disorders thro of inhibition of HMG-CoA decrease the production s. Volume 4(3) 26-31 jalsr.2021.v04i03.004 earch Original Article against et ayudanti g No. 1, Surabaya, d cholesterol levels. in lower cholesterol PL).This study aims to terial and Methods: group consists of five et and three groups of 2.4g/day) of APL leaf s analyzed using the Tukey. Results : The of theatherogenic diet up, treatment with 1.2 w has been shown to the atherogenic diet %.Both APL stew and 69.2%. Conclusion : is 2.4 g becauseit fat, low-fiber, and the risk factors for ed fatty acids can els, while flavonoids sorption of fats that cholesterol levels 19). up of drugs that are of statins associated ough the mechanism A enzymes that can n of mevalonate. In