_____________________________________________________________________________________________________ *Corresponding author: E-mail: segsyn07@gmail.com; Asian Journal of Biotechnology and Genetic Engineering 3(1): 31-40, 2020; Article no.AJBGE.56838 Acute Lead (II) Acetate 3-Hydrate Neurotoxicity Alters Neurocognition and Induced Depressive-like Behavior Via 5-Hydroxytryphtamine, Neurohormone Melatonin and (Na + ,K + )-ATPase Activity in Female Wistar Rats Olusegun G. Adebayo 1,2* , Iheanyichukwu Wopara 3 , Benneth Ben-Azu 4 , W. Aduema 1 , Oluwakemi R. Adebayo 5 and Omeje U. Nicodemus 2 1 Department of Physiology, Neurophysiology Unit, PAMO University of Medical Sciences, Port Harcourt, Nigeria. 2 Department of Physiology, Neurosciences and Oral Physiology Unit, University of Ibadan, Ibadan, Nigeria. 3 Department of Biochemistry, PAMO University of Medical Sciences, Port Harcourt, Nigeria. 4 Department of Pharmacology, Neuropharmacology Unit, PAMO University of Medical Sciences, Port Harcourt, Nigeria. 5 Department of Human Nutrition and Dietetics, University of Ibadan, Ibadan, Nigeria. Authors’ contributions This work was carried out in collaboration among all authors. Author OGA designed the study, performed the statistical analysis, wrote the protocol and wrote the first draft of the manuscript. Authors OGA and IW managed laboratory experiments and the analyses of the study. Author BBA managed the literature searches and methodology. Authors WA and ORA managed the literature searches. Author OUN managed the analyses of the study. All authors read and approved the final manuscript. Article Information Editor(s): (1) Dr. S. Prabhu, Sri Venkateswara College of Engineering, India. Reviewers: (1) Qi Cheng, Chinese Academy of Agricultural Sciences, China. (2) Jihan Seid Hussein, National Research Centre, Egypt. Complete Peer review History: http://www.sdiarticle4.com/review-history/56838 Received 02 March 2020 Accepted 08 May 2020 Published 20 May 2020 Original Research Article