Bisphenol A in infant urine and baby-food samples among 9- to 15-
month-olds
Jangwoo Lee
a
, Young-Ah Ahn
a
, Kyungho Choi
a
, Jeongim Park
b
, Hyo-Bang Moon
c
, Gyuyeon Choi
d
,
Jeong Jae Lee
d
, Eunsook Suh
d
, Hai-Joong Kim
e
, So-Hee Eun
e
, Gun-Ha Kim
e
, Geumjoon Cho
e
, Sung Koo Kim
f
,
Sungjoo Kim
f
, Su Young Kim
g
, Seunghyo Kim
g
, Soyong Eom
h
, Sooran Choi
i
,
Young Don Kim
j
, Sungkyoon Kim
a,
⁎
a
School of Public Health, Seoul National University, Seoul, Republic of Korea
b
College of Natural Sciences, Soonchunhyang University, Asan, Republic of Korea
c
Department of Marine Sciences and Convergence Engineering, Hanyang University, Ansan, Republic of Korea
d
College of Medicine, Soonchunhyang University, Seoul, Republic of Korea
e
College of Medicine, Korea University, Ansan, Republic of Korea
f
College of Medicine, Hallym University, Seoul, Republic of Korea
g
College of Medicine, Jeju National University, Jeju, Republic of Korea
h
College of Medicine, Yonsei University, Seoul, Republic of Korea
i
College of Medicine, Inha University, Incheon, Republic of Korea
j
Department of Pediatrics, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Republic of Korea
HIGHLIGHTS
• The BPA detection frequencies in infant
food and urine were 32.5–76.3% and
85.5–85.7%, respectively.
• The BPA in the baby-food was higher at
15 months relative to 9 or 12 months;
however, BPA in urine was not.
• The baby-food at 15 months, mostly
composed of solid food, contributes to
body burden in infants under 2 years
in Korea.
GRAPHICAL ABSTRACT
abstract article info
Article history:
Received 16 March 2019
Received in revised form 7 August 2019
Accepted 8 August 2019
Available online 09 August 2019
Editor: Adrian Covaci
Diet is the predominant source of bisphenol A (BPA) intake, but limited data are available on BPA levels in the diet
of younger infants. This study investigated BPA levels in baby-food and urine samples collected from young in-
fants (under 2 years old). Samples of homemade baby food (n = 210) and urine (n = 187) were collected at
9, 12, and 15 months after birth from a panel of Korean infants (n = 173). BPA levels in urine and food were mea-
sured using HPLC-MS/MS and GC–MS, respectively. BPA was above the limit of detection (LOD) in 85.5–85.7% of
the urine samples and 32.5–76.3% of the baby-food samples. The median levels of BPA were 0.45 ng/g wet weight
(IQR: not detectable to 5.16 ng/g wet weight) in homemade baby food, 0.93 μg/L (IQR: bLOD to 2.66 μg/L) in
Science of the Total Environment 697 (2019) 133861
⁎ Corresponding author.
E-mail address: ddram2@snu.ac.kr (S. Kim).
https://doi.org/10.1016/j.scitotenv.2019.133861
0048-9697/© 2019 Elsevier B.V. All rights reserved.
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