352 Copyright © 2017, IGI Global. Copying or distributing in print or electronic forms without written permission of IGI Global is prohibited. Chapter 15 DOI: 10.4018/978-1-5225-0585-3.ch015 ABSTRACT In the present study, fsh Labeo rohita were exposed to 20, 50 and 100 µg/L of both Cu NPs and copper sulphate (CuSO 4, bulk copper) for 24 h and hematological profles were estimated. A signifcant (P< 0.01) change in the hemoglobin (Hb), hematocrit (Hct), white blood cells (WBC) and Mean Corpuscular Volume (MCV) levels were observed in all the three concentrations of both bulk and Cu NPs treated fsh when compared to control groups. However a non signifcant change in red blood cells (RBC) (20 and 50 µg/L Cu NPs) and mean corpuscular hemoglobin (MCH) (20 and 50 µg/L bulk Cu) were observed. The alteration in Mean Corpuscular Hemoglobin Concentration (MCHC) value was found to be non signifcant both in bulk and Cu NPs treated fsh. The alterations of these parameters can be used as a potential indicator to examine the health of fsh in aquatic ecosystem contaminated with metal and metal based nanoparticles. Copper and Copper Nanoparticles Induced Hematological Changes in a Freshwater Fish Labeo rohita – A Comparative Study: Copper and Copper Nanoparticle Toxicity to Fish Kaliappan Krishnapriya Bharathiar University, India Mathan Ramesh Bharathiar University, India