Data Extraction: Independent extraction of articles by 3 authors using predefined data fields, as well as the Newcastle-Ottawa Scale for study quality. RESULTS: Data Synthesis: All pooled analyses were based on a random effects model. Five cohort studies and 3 case control studies of patients with IBD on any immuno- suppression with cervical high-grade dysplasia/cancer (n ¼ 995) were included in the meta-analysis. The total IBD population in these studies was 77,116. The duration of follow up and time on immunosuppression was variable but ranged from 2 to 36 years. IBD patients had an increased risk of cervical high-grade dysplasia/cancer compared to healthy controls (OR ¼ 1.34, 95% CI, 1.23–1.46). Heterogeneity was detected (I2 ¼ 34.23, Q ¼ 10.64, df ¼ 7; P ¼ 0.15). The source of this heterogeneity was found to be from the type of study, as well as the OR presented (crude versus adjusted). CONCLUSIONS: Limitations: There were few studies that met the inclusion criteria of comparing the rates of cervical high-grade dysplasia/cancer in patients with IBD on immunosuppressive medication compared to the rates of high-grade dysplasia and cancer in the general population. The heterogeneity within the studies is also a constraint of the results in the study. There is sufficient evidence to suggest there is an increased risk of cervical high-grade dysplasia/cancer in patients with IBD on immunosuppressive medications compared to the general population. Given this increased risk, increased screening intervals are indicated compared to the current screening guidelines for the general population. P-028 Dietary Patterns and Risk of Crohn’s Disease and Ulcerative Colitis Khalili Hamed 1 , Ananthakrishnan Ashwin 1 , Sauk Jenny 1 , Higuchi Leslie 2 , Richter James 1 , Chan Andrew 1 1 Massachusetts General Hospital, Boston, Massachusetts, 2 Boston Children’s Hospital, Boston, Massachusetts BACKGROUND: Westernization of lifestyle, particularly diet through its effect on intestinal gut microbiota, mucosal permeability, and epithelial inflammation likely has had a significant impact on the rising worldwide incidence of Crohn’s disease (CD) and ulcerative colitis (UC). Few studies have examined the association between pre-diagnosis dietary intake and risk of CD and UC. We therefore sought to examine the association between dietary patterns, which provide a more comprehensive picture of the overall impact of foods and nutrients consumed in combinations, and risk of CD and UC. METHODS: We conducted a prospective cohort study of US women enrolled in the Nurses’ Health Study (NHS) and NHSII since 1976 and 1989, respectively. A validated food frequency questionnaire was administered every 4 years starting in 1984 in NHS and 1991 in NHSII with greater than 90% follow-up. Principal component analysis was used to categorize participants according to two major dietary patterns, western dietary pattern characterized by high intake of red meat, sugary desserts, high-fat foods, and refined grains and prudent dietary pattern that includes consumption of high intake of fruits, vegetables, whole- grain foods, poultry, and fish. Diagnoses of CD and UC reported through 2009 in NHSII and 2010 in NHS were confirmed through review of medical records by 2 gastroenterologists blinded to exposure information. We used Cox proportional hazards models to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) adjusted for age, smoking, body mass index, physical activity, history of appendectomy, and use of oral contraceptives, menopausal hormone therapy, or non-steroidal anti-inflammatory drugs. RESULTS: Among a total of 181,843 women, we documented 256 cases of CD and 318 cases of UC over 24 years of follow up encompassing 3,365,623 person-years. Western dietary pattern did not appear to be associated with risk of CD (P linear trend ¼ 0.56). Compared to women in the lowest quintile of western dietary pattern, the multivariate-adjusted HRs of CD were 0.96 (95% CI, 0.57–1.63) for those in quintile 2; 0.90 (95% CI, 0.53–1.52) for quintile 3; 1.16 (95% CI, 0.70– 1.92) for quintile 4; and 1.07 (95% CI, 0.63–1.80) for highest quintile. Similarly, we did not observe an association between prudent dietary pattern and risk of CD (P linear trend ¼ 0.26). Compared to women in the lowest quintile of prudent dietary pattern, the multivariate-adjusted HRs of CD were 1.31 (95% CI, 0.79–2.18) for those in quintile 2; 1.44 (95% CI, 0.88–2.38) for quintile 3; 0.67 (95% CI, 0.37– 1.23) for quintile 4; and 0.99 (95% CI, 0.56–1.74) for highest quintile. Neither western nor prudent dietary patterns were associated with risk of UC (P linear trend ¼ 0.20 and 0.32, respectively). CONCLUSIONS: In 2 large prospective cohorts of US women, western and prudent dietary patterns during adulthood were not associated with late-onset CD or UC. Future studies on the interaction between dietary patterns and CD/ 2014 IBD Abstracts S36