Page S1 Supporting Information “Inverse” Synthesis of Polymer Bioconjugates using Soluble Supports. Anna Meszynska 1 , Nezha Badi 1 , Hans Börner 2 and Jean-François Lutz 1* 1 Precision Macromolecular Chemistry Group, Institut Charles Sadron, UPR-22 CNRS, BP 84047, 23 rue du Loess, 67034 Strasbourg Cedex 2, France 2 Laboratory of Organic Synthesis of functional Systems, Humboldt-Universität zu Berlin, Brook-Taylor-Str. 2, 12489 Berlin, Germany *E-Mail: jflutz@unistra.fr Content: A. Experimental procedures. A.1. Chemicals S2 A.2. Synthesis of ATRP initiator 1 S2 A.3. Synthesis of ATRP initiator 2 S3 A.4. Synthesis of cleavable support P4 S3 A.4.1. ATRP (P1) S3 A.4.2. Deprotection of Fmoc group (P2) S4 A.4.3. Attachment of a Wang linker (P3) S4 A.4.4. Loading of glycine (P4) S4 A.5. Synthesis of permanent support P5 S4 A.6. General procedure for peptide coupling S4 A.7. Cleavage of the peptide from the cleavable support S5 A.8. Selective deprotection of the side groups S5 A.9. Solid-phase automated synthesis of the control peptide GKYGKY S5 B. Measurements and analysis. B.1. Size Exclusion Chromatography (SEC) S6 B.2. Nuclear Magnetic Resonance (NMR) S6 B.3. Electrospray Liquid Chromatography Mass Spectrometry (ESI-LC-MS) S6 B.4. MALDI-TOF Mass Spectrometry S6 C. Additional data and Figures. Figure S1 S7 Figures S2 and S3 S8 Figures S4 and S5 S9 Tables S1 and S2 S10 Electronic Supplementary Material (ESI) for Chemical Communications This journal is © The Royal Society of Chemistry 2012