Jebmh.com Original Article J. Evid. Based Med. Healthc., pISSN- 2349-2562, eISSN- 2349-2570/ Vol. 3/Issue 57/July 18, 2016 Page 2937 STUDY OF GASTRIC BIOPSIES WITH CLINICOPATHOLOGICAL CORRELATION – A TERTIARY CARE CENTRE EXPERIENCE Anunayi Jeshtadi 1 , Afzal Moid Mohammad 2 , Madhukar Reddy Kadaru 3 , Ezhil Arasi Nagamuthu 4 , Harika Kalangi 5 , Archana Boddu 6 , Sandeep Kumar Lakkarasu 7 , Ajeta Boila 8 1 Associate Professor, Upgraded Department of Pathology, Osmania Medical College. 2 Assistant Professor, Upgraded Department of Pathology, Osmania Medical College. 3 Senior Resident, Upgraded Department of Pathology, Osmania Medical College. 4 Professor & HOD, Upgraded Department of Pathology, Osmania Medical College. 5 Junior Resident, Upgraded Department of Pathology, Osmania Medical College. 6 Senior Resident, Upgraded Department of Pathology, Osmania Medical College. 7 Senior Resident, Upgraded Department of Pathology, Osmania Medical College. 8 Senior Resident, Upgraded Department of Pathology, Osmania Medical College. ABSTRACT BACKGROUND Gastric disorders are one of the most commonly encountered problems in clinical practice. A variety of disorders can affect the stomach and gastrointestinal tract. The definitive diagnosis of gastric disorders rests on the histopathological confirmation and is one of the basis for planning proper treatment. OBJECTIVES To determine the spectrum of histopathological lesions of gastric region. To establish endoscopic biopsies as an effective tool in the proper diagnosis and management of various gastric lesions. MATERIALS AND METHODS A retrospective study was conducted on the gastric endoscopic biopsies and the histopathological assessment was done at the Department of Pathology, Osmania Medical College and Teaching Hospital from November 2014 to October 2015. RESULTS Of the total 87 cases of gastric biopsies, majority of cases were of male gender with a male-female ratio of 2.4:1. Our study showed a poor correlation between endoscopic and histopathological evidence of inflammation in the stomach. Four cases were diagnosed as intestinal metaplasia which were diagnosed as ulcer and erosion endoscopically. Out of 23 number of cases diagnosed endoscopically as ulcer, only one case was confirmed histopathologically. Our study showed good correlation in the cases of carcinoma. All 38 cases diagnosed endoscopically as gastric carcinoma correlated histopathologically as gastric adenocarcinoma. Majority of carcinoma cases showed ulcerating fungating growth followed by ulceroproliferative growth. CONCLUSION In our study, the commonest site for endoscopic biopsy was from the stomach in which fundus region and antral region account the most. Most common neoplasm of the stomach was adenocarcinoma. Endoscopy is incomplete without biopsy and histopathology is the gold standard for the diagnosis of endoscopically detected lesions. We, therefore, conclude that endoscopy is incomplete without biopsy and so the combination of methods provides a powerful diagnostic tool for better patient management. KEYWORDS Endoscopic Biopsy, Histopathology, Adenocarcinoma, Helicobacter Pylori, Peptic Ulcer. HOW TO CITE THIS ARTICLE: Jeshtadi A, Mohammad AM, Kadaru MR, et al. Study of gastric biopsies with clinicopathological correlation – A tertiary care centre experience. J. Evid. Based Med. Healthc. 2016; 3(57), 2937-2940. DOI: 10.18410/jebmh/2016/639 INTRODUCTION: Human gastrointestinal tract which is long and tortuous is an common site for lesions like congenital, inflammatory and neoplastic conditions. 1,2,3 In the upper gastrointestinal tract most commonly encountered problem in the clinical practice is gastric lesions with a high degree of morbidity and mortality and endoscopic biopsy is common procedure performed in the hospital for a variety of benign and malignant lesions. 4 Financial or Other, Competing Interest: None. Submission 10-06-2016, Peer Review 20-06-2016, Acceptance 09-07-2016, Published 15-07-2016. Corresponding Author: Dr. Madhukar Reddy Kadaru, Senior Resident, Upgraded Department of Pathology, Osmania Medical College, Koti, Hyderabad, Telangana. E-mail: mkadaru@gmail.com DOI: 10.18410/jebmh/2016/639