*Correspondence: dsoren@ravenshawuniversity.ac.in (Received: August 15, 2021; accepted: December 13, 2021) Citaton: Mohanty JR, Pradhan A, Jena S, Padhi BK, Das P, Soren D. Antbiotc Resistance Patern of Uropathogens among Non Pregnant Women: A Hospital based Cross Sectonal Study from Odisha. J Pure Appl Microbiol. 2022;16(1):296-304. doi: 10.22207/JPAM.16.1.18 © The Author(s) 2022. Open Access. This artcle is distributed under the terms of the Creatve Commons Atributon 4.0 Internatonal License which permits unrestricted use, sharing, distributon, and reproducton in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creatve Commons license, and indicate if changes were made. Mohanty et al. | J Pure Appl Microbiol | 16(1):296-304 | March 2022 Artcle 7250 | htps://doi.org/10.22207/JPAM.16.1.18 Published Online February 5, 2022 Print ISSN: 0973-7510; E-ISSN: 2581-690X ReseARCh ARtiCle OPeN ACCess www.microbiologyjournal.org 296 Journal of Pure and Applied Microbiology Antbiotc Resistance Patern of Uropathogens among Non Pregnant Women: A Hospital based Cross Sectonal Study from Odisha Jyot Ranjan Mohanty 1,2 , Alisha Pradhan 3 , Sunita Jena 4 , Bijaya Kumar Padhi 5 , Padmalaya Das 6  and Dhananjay Soren 1,2 * 1 Department of Zoology, Ravenshaw University, Cutack - 753 003, Odisha, India. 2 Centre for Excellence in Environment and Public Health, Ravenshaw University, Cutack - 753 003, Odisha, India. 3 Natonal Health Mission, Annex Building, State Insttute of Health and Family Welfare, Unit-8, Bhubaneswar - 751 012, India. 4 All India Insttute of Medical Science, Bhubaneswar - 751 019, Odisha, India. 5 Department of Community Medicine and School of Public Health, Post Graduate Insttute of Medical Educaton & Research, Chandigarh - 160 012, India. 6 School of Biological Sciences, AIPH University, Bhubaneswar - 752 101, Odisha, India. Abstract Urinary tract infecton (UTI) is one of the most delicate health problem afectng women with severe complicatons and the rising antmicrobial resistance exerts a massive infuence in treatng UTIs. The objectves of this study was to identfy the uropathogens causing UTI in non-pregnant women and their antbiotc resistance patern. The study was undertaken in the outpatent department (OPD) of Obstetrics and Gynaecology, Capital Hospital, Bhubaneswar, Odisha during April 2015 to March 2016. A total of 766 midstream urine samples (MSU) was collected from women of diferent age. Out of 766 urine samples, 323 (42.1%) samples were culture positve for UTI with prominent bacteriuria. E.coli was found to be the most common isolate (54.79 %) followed by Staphylococcus sp. (22.6%), Enterobacter sp. (17.64%) and Klebsiella sp. (4.95%). Amongst various clinical symptoms, burning and itching during urinaton was found to be the most common (69.97%) symptoms followed by abnormal discharge of the vagina (45.20%) and the presence of cloudy urine (24.46%). E.coli the most predominant uropathogen identfed was found to be highly susceptble towards a low level of resistance towards nitrofurantoin (11.8%) followed by amikacin (20.03%) and gentamicin (22.0%). Our study revealed that E. coli isolates were the predominant uropathogens and showed escalatng model of resistance to the general available antmicrobial agents which are frequently used by the physicians in hospitals and private practce. Keywords: Urinary Tract Infectons, Antbiotc resistance, Uropathogens, Bacteriuria, Ant Microbial agents