Page-102 Orginal Article Shabzain Ishrat, Talea Hoor, Muhammad Sajid Abbas Jaffri, Shizma Junejo, Mehreen Lateef ABSTRACT Objectives: To evaluate the effects of adjuvant vitamin C therapy with oral hypoglycemic on FBS, RBS and HbA1c and to find out the correlation of Vitamin C with glycemic indices. Study Design & Settings: This randomized open label clinical trial was conducted at Bahria University Medical & Dental College (BUMDC) in collaboration with NMC, Karachi from October 2018 to April 2019. Methodology: A total of 160 known type -2 males and females, uncomplicated diabetics, aged 40-65 years with FBS= 200 mg/dl, HbA1c = 8.5% and diabetes duration > 5years were enrolled from diabetic clinic of NMC after written informed consent. They were divided into control group and treatment group by sealed envelope technique. Control group received oral hypoglycemic drugs while treatment group received vitamin C 500 mg per orally BD with oral hypoglycemic drugs with advice of diet control and daily exercise. Patients were subjected to FBS, RBS and HbA1c at baseline and at the end of 90 days. SPSS version 23.0 was used for data analysis. The results were expressed as mean ± standard deviation (SD). P value<0.05 was considered as statistically significant. Results: In control group FBS and RBS reduced by1mg /dl and 7mg/dl from day-0 to 90. In treatment group FBS reduced by 14mg/dl and RBS reduced by 21mg/dl from day-0 to 90. HbA1c increased by 0.7% in control group and decreased by 0.4 % in treatment group at the end of 90 days. Negative correlation is observed between Vitamin C and glycemic indices. Conclusion: Adjuvant vitamin C therapy with oral hypoglycemic drugs in type-2 diabetics reduced FBS, RBS and HbA1c and exhibited negative correlation with glycemic parameters. Keywords: Correlation, Fasting blood sugar, HbA1c, Random blood sugar, Type 2 diabetes mellitus, Vitamin C. 90% to 95% of the diabetic patients. 6,7 International Diabetes Federation (IDF) has estimated that 1 in 11 adults were diagnosed with type 2 DM in 2015 and has predicted that there will be 642 million people with type 2 DM in 2045. The disease is more common in developing countries as compared to developed nations. 8 According to IDF, Pakistan has high prevalence of disease and is in the list of top ten countries with increased prevalence of type 2 DM. About 6.6 million people live with type 2 diabetes in Pakistan. 9 Pakistan is the sixth most populous country and the trend for urbanization has increased in the recent years. Sedentary lifestyle, increased consumption of high calorie diet, lack of exercise and stressful conditions has led to increased prevalence of disease in Pakistan. 10 Long standing hyperglycemia of type 2 diabetes mellitus leads to increase in oxidative stress by production of reactive oxygen species. These reactive oxygen species lead to progression of disease into complicated diabetes mellitus which includes micro- vascular and macro-vascular complications. 11 It has been reported by various studies that there is a strong association between oxidative damage and progression of disease. The imbalance between the rate of production of reactive oxygen species and to counteract them by antioxidants is the main Impact of Vitamin C as an Adjuvant Agent on Glycemic Indices in Type 2 Diabetes Mellitus: Randomized Clinical Trial How to cite this Article: Ishrat S, Hoor T, Jaffri MSA, Junejo S, Lateef M. Impact of Vitamin C as an Adjuvant Agent on Glycemic Indices in Type 2 Diabetes Mellitus: Randomized Clinical Trial. J Bahria Uni Med Dental Coll. 2021; 11(3):102-106 DOI: https://doi.org/10.51985/MYDD5410 This is an Open Access article distributed under the terms of the Creative Commons Attriution Non Commercial Liciense (http:// creativecommons/org/licences/by-nc/4.0) which permits unrestricted non commercial use, distribution and reproduction in any medium, provided the original work is properly cited. INTRODUCTION: Diabetes mellitus (DM) is a metabolic disorder characterized by elevated levels of blood glucose. It is one of the oldest diseases known to mankind. 1 Type 2 DM is characterized by hyperglycemia, hyperlipidemia, insulin resistance etc; caused by gradual destruction of â cells. 2,3, 4,5 It accounts for JBUMDC 2021;11(3):102-106 Open Access Shabzain Ishrat Senior Demonstrator, Department of Pharmacology, Shahida Islam Medical and Dental College, Lodhran Email: ishabzain@hotmail.com Talea Hoor Professor, Department of Pharmacology, Bahria University Medical and Dental College, Karachi Muhammad Sajid Abbas Jaffri Professor, Department of Medicine, Bahria University Medical and Dental College, Karachi Shizma Junejo Senior Lecturer, Department of Biochemistry, Bahria University Medical and Dental College, Karachi Mehreen Lateef Assistant Professor, Department of MDRL, Bahria University Medical and Dental College, Karachi Received: 28-10-2020 Accepted: 14-06-2021