Revista Medicală RoMână – VoluMul lXVi, Nr. 2, An 2019 158 PREZENTĂRI DE CAZ Mammary cancer: Sneak peek to thyroid nodules Diana Loreta Paun 1,2, Mara Carsote 1,2 , Ana Valea 3,4 , Ancuta Augustina Gheorghisan-Galateanu 1,2 , Rucsandra Danciulescu-Miulescu 1,5 , Adina Ghemigian 1,2 Corresponding author: Assist. Prof. Mara Carsote, MD, PhD E-mail: carsote_m@hotmail.com ABSTRACT Breast cancer has a worldwide increasing incidence and once the diagnosis is done a screening is performed using method like ultrasound, computed tomography etc in order to assess disease spreading, according to the mammary malignancy’s stage. During this type of evaluation, a thyroid condition might be detected. Generally, 50-70% of adult population has a thyroid nodule of different dimensions, usually with a very low clinical relevan- ce and a very good prognosis. If the pathogenic correlation between a thyroid nodule and the breast tumour is indeed sustained this is still a matter of debate. Our purpose is to introduce a series of subjects associating non-syndromic mammary cancer and thyroid nodules of various types. The use of thyroid ultrasound in patients with mammary cancer is mandatory. Most of thyroid nodules are incidental but some thyroid pathologies may actually be linked to breast malignancy. Keywords: breast cancer, ultrasound, thyroid nodule InTRoduCTIon Breast cancer has an increasing incidence and once the diagnosis is established a screening using ultrasound, computed tomography or magnetic res- onance imagery for adequate assessment of the dis- ease spreading is frequently useful, according to the mammary malignancy’s stage (1,2,3). On the other hand, if performed imagery, 50-70% of adult population has a thyroid nodule of different dimen- sions, usually with a very low clinical relevance (4,5,6). Thus in particular cases priorly confirmed with a cancer diagnosis, the risk of incidental find- ing regarding a thyroid nodule is very high (4,5,6). Clinical detection in general population reveals that 5% of women coming from non-endemic areas have a thyroid nodule (5). The incidence is age re- lated (5). Overall, the risk of thyroid cancer in a thyroid incidentaloma is 7-15% (5). The term of thyroid “incidentaloma” is not routinely used for thyroid as seen in adrenal and pituitary incidentalo- ma, being preferred a rather general term of thyroid “nodule” (7,8,9). If the pathogenic correlation be- tween a thyroid nodule and the breast tumour is in- deed sustained this is still a matter of debate (10,11,12). The risk of thyroid metastasis in breast cancer is extremely low while the synchronous di- agnosis of a second malignancy like a differentiat- ed thyroid cancer is considered in majority of cases circumstantial, except for rare common genetic background (13,14,15). AIm Our purpose is to introduce a series of subjects associating non-syndromic mammary cancer and thyroid nodules. Also, particular endocrine aspects as bone status or hyperprolactinemia are displayed in addition to mammary malignancy. meThod This is a case presentation. The gynaecological endocrine and oncologic profile is provided. Ref: Ro Med J. 2019;66(2) DOI: 10.37897/RMJ.2019.2.13 1 Department of Gynaecology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania 2 Constantin Ion Parhon National Institute of Endocrinology, Bucharest, Romania 3 Department of Endocrinology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania 4 Department of Endocrinology, Clinical County Hospital, Cluj-Napoca, Romania 5 Nicolae Paulescu National Institute, Bucharest, Romania Article History: Received: 17 May 2019 Accepted: 1 June 2019