Iranian Journal of Organic Chemistry Vol. 11, No. 2 (2019) 2625-2631 N. Ghasemi et.al. 2625 KF/CP NPS promoted synthesis of lactones through the reaction of OH-acids with activated acetylenes Narges Ghasemi a *, Faramarz Rostami-Charati b,c , Reza Akbari b a National Petrochemical Company (NPC), petrochemical Research and Technology Company, Arak Center, Iran b Department of Chemistry, Facualty of Science, Gonbad Kavous University, P.O.Box 163,Gonbad, Iran. c Research Center for Conservation of Culture Relics (RCCCR), Research institute of Cultural Heritage & Tourism, Tehran, Iran. Received: February 2019; Revised: March 2019; Accepted: March 2019 Abstract: The reaction between propiolate and various OH-acids such as phenol, 1-naphthol, 2-naphthol, 8-hydroxyquinoline, 1,6-dihydroxynaphthalene, cathechol, hydroquinone, or resorcinol in the presence of catalytic amounts of KF/Clinoptilolite nanoparticles leads to lactone derivatives in good yields. Keywords: Propiolate, Phenol, 1-naphthol, 2-naphthol, 8-hydroxyquinoline, 1,6-dihydroxynaphthalene. Introduction The lactones are an important structure unit in natural products and intermediates in organic synthesis. There has been considerable work on the synthesis of these compounds due to the discovery of many naturally occurring cytotoxic or antitumor agents. Although this ring system has been the objective of synthestic projects in a number of laboratories [1-3], the number of basically different approaches is not large. Multicomponent reactions are very significant in organic synthesis because of the creation of carbon- carbon and carbon-hetero atom bonds in one pot [4-6]. Some advantages of these reactions include easy and clean procedures, producing of high yield bond formation, consuming of low time and energy, and low costs are among [7]. On the past few years, chemists have been informed about the environmental conditions and performing the reaction in green conditions. *Corresponding author: Tel: 0098-8633677201-9; Fax: 0098- 8633677203, E-mail: naghasemi.16@gmail.com Therefore, they are attempted to expand new synthetic procedures, reaction conditions, and employing of materials that decrease the dangers to persons and the environment. Organic solvents are hazardous because they are frequently volatile liquids and employed alot. Therefore, in recent years, performing organic reactions under solvent-free conditions is interest because of high yields, easy separation of product and catalyst, low costs, mild reaction conditions and low pollution [8-10]. Chemistry of heterocyclic compounds has been studied in several subjects such as natural products, biologically active agrochemicals, pharmaceutical agents and organic materials [11]. KF/CP that is used as a new natural and economical solid base synthesized from putting Potassium fluoride on clinoptilolite as a new natural and inexpensive solid base system [12-20]. Clinoptilolite is a natural zeolite with a high internal surface area. It is precious because of its high replacing capability for cations mainly for K+. Therefore, more free fluoride anions act as good base. In contrast, the preparation of clinoptilolite (KF/CP) is very easy without the need for any pre-activation [21-23]. Herein