Vol. 3, Issue 9, pp 47-50, Winter 2019 ORIGINAL ARTICLE Protective Role of Folic Acid in Oxidative Stress Induced by Methionine over Load on Lipids and Lipoproteins Levels in Female New Zealand Rabbits Ruqaih Kareem Mohammed AL- kenany 1 , Saad H.Abd-Altaif 2 and Wefak Gaborry Al- Bazii 3 1 Department of Clinical Laboratories, College of Applied Medical Sciences, University of Karbala, Karbala, Iraq. 2 Department of Biology, College of Pure sciences Education, University of Karbala, Karbala, Iraq. 3 College of Veterinary Medicine, University of Karbala, Karbala, Iraq. ARTICLE INFORMATIONS Article History: Submitted: 8 January 2019 Revised version received: 22 February 2019 Accepted: 23 February 2019 Published online: 1 March 2019 Key words: Methionine Folic Acid New Zealand Rabbits Lipoproteins Corresponding author: Ruqaih Kareem Mohammed AL- kenany Email: rouqaia.kareem1982@gmail.com Department of Clinical Laboratories College of Applied Medical Sciences University of Karbala Karbala Iraq ABSTRACT Objectives: The aim of this study was examine to know protective role of folic acid in oxidation stress that results by over load of methionine. Methods: In these study used 18 female of New Zealand rabbits . the working including measuring the TC,TG,HDL,LDL and VLDL levels in blood after intubated over load of methionine and compered with control. Results: The results show that a significant decrease (p<0.05) in HDL levels and a significant increase (p<0.05) in TC, TG, LDL and VLDL in G2 compared with G1 and G3. Conclusion: From the results of the present study , we can be concluded that methionine overload state effects on lipids and lipoproteins and folic acid have protective role in oxidative stress that resulted by over load methionine. Copyright©2019, Ruqaih Kareem Mohammed AL- kenany. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited. INTRODUCTION Methionine is essential amino acid witch contain sulfur , it is found in rice , cazain, cheese , eggs , meet and fish 1 . Methionine considers essential source of sulfur and many compounds necessary for body and sulfur have important role in (lecithin) production witch it important in decrease the lipids in liver and methionine have important role in (urolithiasis) 2 , and it is source of homocysteine in blood and over load of methionine lead to Hyperhomocystinemia (HHcy). HHcy lead to coronary arteries disease and myocardial infraction by oxidative stress 3 . Cholesterol is a fat, waxy substance and it is found in the cells of the body and it important to make hormones ,vitamin D and help in digest foods 4 . Cholesterol is made in the body and also found in animals sources egg yolks, meat and cheese 5 . Triglyceride (TG) is a type of fat and found in adipose Available online at http://www.sjomr.org SCIENTIFIC JOURNAL OF MEDICAL RESEARCH Citation: Al- kenany R.K.M., Abd-Altaif S.H. and Al-Bazii W.G. “Protective Role of Folic Acid in Oxidative Stress Induced by Methionine over Load on Lipids and Lipoproteins Levels in Female New Zealand Rabbits”. Sci. J. Med. Res. 2019; 3 (9): 47-50. ISSN: 2520-5234 Sci. J. Med. Res., Vol. 3, Issue 9, pp 47- 50, Winter 2019 47 .