ARC Journal of Dental Science Volume 1, Issue 3, 2016, PP 23-26 ISSN No. (Online): 2456-0030 DOI: http://dx.doi.org/10.20431/2456-0030.0103005 www.arcjournals.org ©ARC Page | 23 Evaluation of Anti Ulcer Activity of Ethanolic Extract of Aegle Marmelos Leaves on Rats Dr. Sharmin Rahman, Dr. Mohammad Rezaul Quader, Dr Rayhana Sharmin, Dr Azmary Momtaz, Dr Khaleda Sharmin, Dr. Eliza Omar Eva, Dr. Abu Syed Md. Mosaddek, 1 Assistant Professor, Department of Pharmacology and Therapeutics, Ibrahim Medical College, Dhaka, Bangladesh. 2 Lecturer, Department of Biochemistry, Shaheed Suhrawardy Medical College, Dhaka, Bangladesh. 3 Lecturer, Department Pharmacology and Therapeutics, Uttara Adhunik Medical College, Dhaka, Bangladesh. 4 Assistant Professor, Department of Pharmacology and Therapeutics, Delta Medical College, Dhaka, Bangladesh. 5 Assistant Professor, Department of Pharmacology and Therapeutics, University Dental College, Dhaka, Bangladesh. 6 Associate Professor, Department of Pharmacology and Therapeutics, Dhaka Medical College, Dhaka, Bangladesh. 7 Professor and head, Department of Pharmacology and Therapeutics, Uttara Adhunik Medical College, Dhaka, Bangladesh (Correspondent). Abstract: Background: Peptic ulcer disease is a serious gastrointestinal disorder that requires a well targeted therapeutic strategy. A number of drugs including proton pump inhibitors and H 2 receptor antagonists are available for the treatment of peptic ulcer, but clinical evaluation of these drugs has shown incidence of relapses, side effects and drug interactions. Herbal medicine deals with plants and plant extracts in treating diseases. Bangladesh is a rich emporium of medicinal plants useful in treatment of various disorder including petric ulcer. Objective: Aegle marmelos is used as ethno medicine against various human ailments. Several crude extracts of this plants have been investigated and shown to have wide range of pharmacological effects. Although aqueous and other leaf extracts of Aegle marmelos have been studied for anti ulcer activity, no reports was found on ethanolic extract of leaves. Hence the present work was planned to investigate the anti ulcer actively, claimed traditionally. Materials and methods: The ethanolic extract of Aegle marmelos leaves at 400mg/kg body weight was studied for ulcer protective activity by ethanol induced gastric ulcer method. Results: Ethanolic extract exhibited significant (P<0.001) anti ulcer activity in ethanol induced gastric ulcer model used. Percentage protection of ulcer with ethanolic extract of Aegle marmelos was 56.33% compared to standard anti ulcer drug Omeprazole (50.44%). Conclusion: This present study indicates that ethanolic extract of Aegle marmelos leaves have potential anti ulcer activity. Keywords: Aegle marmalos leaves, anti ulcer. 1. INTRODUCTION Petric ulcer is one of the most prevalent gastro intestinal disorder, which effects approximately 5-10% of people during their life. The major factors that causes peptic ulcer are infection with gram negative Helicobacter pylori, increased hydrochloric acid secretion, inadequate mucosal defence against gastric acid, drugs like the cholinergic drugs. NSAIDs and improper food intake 1 . In recent years, plentiful works have been carried out on herbal medicine to clarify their potential efficacy in gastric ulcer prevention and management. Aegle marmelos commonly known as Bael is one of the indigenous plants that is readily available and has been traditionally used to improve gastro intestinal disorders. Extensive chemical investigations