Cronicon OPEN ACCESS EC GYNAECOLOGY EC GYNAECOLOGY Research Article Prenatal Diagnosis of Congenital Anterior Abdominal Wall Defects in Villa Clara, Cuba, 1994 - 2019: A Retrospective Analysis Noel Taboada Lugo 1 *, Ana E Algora Hernández 2 , Gisela Noche González 3 , Manuela Herrera Martínez 4 , Lorna González Herrera 5 , Eliecer Anoceto Armiñana 6 and Dagny de J Monteagudo Morales 7 1 Medical Doctor, Family Medicine Specialist, Clinical Genetics Specialist, Master’s Degree in Comprehensive Child Health, Associate Professor of the Medical University of Villa Clara, Cuba 2 Medical Doctor, Clinical Genetics Specialist, Master´s Degree in Public Health, Associate Professor of the Medical University of Villa Clara, Cuba 3 Medical Doctor, Family Medicine Specialist, Master´s Degree in Genetic Counseling, Associate of the Medical University of Villa Clara, Cuba 4 Medical Doctor, Clinical Genetics Specialist, Doctorate in Medical Sciences, Full professor of the Medical University of Villa Clara, Cuba 5 Medical Doctor, Terminal Professional Degree in Radiology, Assistant Professor of Medical Genetics at the Villa Clara Medical University, Cuba 6 Medical Doctor, Pathological Anatomy Specialist, Associate Professor of the Medical University of Villa Clara, Cuba 7 Medical Doctor, Family Medicine Specialist, Toxicomania Unit, Oviedo, Princedom of Asturias, Spain Citation: Noel Taboada Lugo., et al. “Prenatal Diagnosis of Congenital Anterior Abdominal Wall Defects in Villa Clara, Cuba, 1994 - 2019: A Retrospective Analysis”. EC Gynaecology 10.6 (2021): 08-18. *Corresponding Author: Noel Taboada Lugo, Medical Doctor, Family Medicine Specialist, Clinical Genetics Specialist, Master’s Degree in Comprehensive Child Health, Associate Professor of the Medical University of Villa Clara, Cuba. Received: April 29, 2021; Published: May 05, 2021 Abstract Objectives: To describe trends in prevalence of the abdominal wall defects, maternal age-specific prevalence and accuracy of prenatal diagnosis methods. Methods: Retrospective analysis using data from Registries of Congenital Malformations in Villa Clara province, Cuba; from 1994 to 2019. Results: The prevalence of abdominal wall defects was 8.47 per 10,000 live births. There was an increase of 34.6% of the overall prev- alence. Gastroschisis had the highest increase (36.51%) from 4.30 to 5.87 per 10,000 live births. Gastroschisis was associated with an increased risk for youngest mothers (< 20 years of age) (OR = 3.78; CI = 1.64 - 3.37), whereas for omphalocele it was for women aged ≥ 35 years (OR = 4.22; CI = 2.3 - 7.78). The sensitivity of antenatal diagnosis of anterior abdominal wall defects by ultrasonography was 42.7% and by serum alpha-fetoprotein was 74.2%, with major accuracy of alpha-fetoprotein for gastroschisis (88.9%) and ultra- sonography for omphalocele (65.9%) (p < 0,01 and p = 0, 01, respectively). Conclusion: A rising prevalence trend has been noted in recent decades in Villa Clara. The present study revealed a pattern for young mothers of cases with gastroschisis and older maternal age for omphalocele. The use of fetal ultrasound and alpha-fetoprotein screening allowed the prenatal diagnosis of the majority of cases in Villa Clara. Keywords: Prenatal Diagnosis; Abdominal Wall Defects; Gastroschisis; Omphalocele; Cuba