Synthesis of new transition metal complexes of 1H-perimidine derivatives having antimicrobial and anti-inflammatory activities Fatma A. Bassyouni • Sherifa M. Abu-Bakr • Khaled H. Hegab • Wafaa El-Eraky • Ahmed A. El Beih • Mohamed E. Abdel Rehim Received: 27 September 2011 / Accepted: 29 December 2011 / Published online: 18 February 2012 Ó Springer Science+Business Media B.V. 2012 Abstract New series of 1H-perimidine-2-thiol derivatives and (2-substituted-1H- perimidin-1-yl)ethane-1,2-dione derivatives and their ligands (C 24 H 14 N 4 S 2 O 2 )H 2 L 1 and (C 26 H 18 N 4 S 2 O 2 )H 2 L 2 have been synthesized with transition metal ions, e.g., Copper (II), Silver (I), Cobalt (II) and Ruthenium (III) were prepared and evaluated for their antimicrobial, analgesic and anti-inflammatory activities. The synthesized compounds and their complexes were characterized by elemental analysis, 1 H NMR, IR, MS, molar conductance, thermal gravimetric analysis and electronic spectra. All results revealed that compounds 3 and 13 exhibited high inhibitory F. A. Bassyouni (&)  A. A. El Beih Chemistry Department of Natural and Microbial Products and Pharmaceutical Research Department, Center of Excellence for Advanced Sciences, National Research Centre, Cairo 12622, Egypt e-mail: fatma.nrc@hotmail.com A. A. El Beih e-mail: aae2eg@yahoo.com S. M. Abu-Bakr Chemistry Department of Natural and Microbial Products, National Research Centre, Cairo 12622, Egypt e-mail: sherifakandel@hotmail.com K. H. Hegab Department of Inorganic Chemistry and Pharmaceutical Research Department, Center of Excellence for Advanced Sciences, National Research Centre, Cairo 12622, Egypt e-mail: kh19salm@hotmail.com W. El-Eraky Department of Pharmacology, National Research Centre, Cairo 12622, Egypt e-mail: wafaa_nrc@yahoo.com M. E. A. Rehim Department of Analytical Chemistry, Stockholm University, 10691 Stockholm, Sweden e-mail: mohamed.abdel-rehim@anchem.su.se 123 Res Chem Intermed (2012) 38:1527–1550 DOI 10.1007/s11164-011-0482-9