_____________________________________________________________________________________________________ *Corresponding author: E-mail: dr.dhirendra27@gmail.com; Journal of Pharmaceutical Research International 33(53A): 67-78, 2021; Article no.JPRI.77075 ISSN: 2456-9119 (Past name: British Journal of Pharmaceutical Research, Past ISSN: 2231-2919, NLM ID: 101631759) A Comparative Evaluation between the Efficacy of Scaling & Root Planing (SRP) with Local Delivery of Chlorhexidine Gluconate and SRP Alone in Periodontal Pocket Reduction Therapy Dhirendra Kumar Singh a* , Gunjan Kumar b , Jugajyoti Pathi c , Md Jalaluddin a , and Samikshya Jena b a Department of Periodontics & Oral Implantology, Kalinga Institute of Dental Sciences, KIIT Deemed to be University, Bhubaneswar, India. b Department of Public Health Dentistry, Kalinga Institute of Dental Sciences, KIIT Deemed to be University, Bhubaneswar, India. c Department of Oral and Maxillofacial Surgery, Kalinga Institute of Dental Sciences, KIIT Deemed to be University, Bhubaneswar, India. Authors’ contributions This work was carried out in collaboration among all authors. All authors read and approved the final manuscript. Article Information DOI: 10.9734/JPRI/2021/v33i53A33640 Editor(s): (1) Dr. Aurora Martínez Romero, Juarez University, Mexico. Reviewers: (1) Daljeet Singh Dhanjal, Lovely Professional University, India. (2) Eddy Bagus Wasito, Universitas Airlangga, Indonesia. (3) Sofia Februanti, Poltekkes Kemenkes Tasikmalaya, Indonesia. Complete Complete Peer review History, details of the editor(s), Reviewers and additional Reviewers are available here: https://www.sdiarticle5.com/review-history/77075 Received 10 September 2021 Accepted 20 November 2021 Published 04 December 2021 ABSTRACT Aim: The aim of the present study was to compare the efficacy of locally delivered chlorhexidine as an adjunct to scaling and root planning (SRP) & SRP alone in bringing reduction of pocket depth in the treatment of moderate to severe periodontitis patients. Materials and Methods: A total number of 15 patients both males and females in the age group of 30-55 years were selected with total number of 30 sites with periodontal probing pocket depth measuring 5-8mm in different quadrant of the mouth. A randomized, double blind, controlled clinical trial design was followed for the study. On one side scaling and root planning was done and on the Original Research Article