Accepted Manuscript Structure-based identification of a NEDD8-activating enzyme inhibitor via drug repurposing Ke-Jia Wu, Hai-Jing Zhong, Guodong Li, Chenfu Liu, Hui-Min David Wang, Dik-Lung Ma, Chung-Hang Leung PII: S0223-5234(17)31004-8 DOI: 10.1016/j.ejmech.2017.11.101 Reference: EJMECH 9976 To appear in: European Journal of Medicinal Chemistry Received Date: 7 September 2017 Revised Date: 27 November 2017 Accepted Date: 29 November 2017 Please cite this article as: K.-J. Wu, H.-J. Zhong, G. Li, C. Liu, H.-M. David Wang, D.-L. Ma, C.-H. Leung, Structure-based identification of a NEDD8-activating enzyme inhibitor via drug repurposing, European Journal of Medicinal Chemistry (2018), doi: 10.1016/j.ejmech.2017.11.101. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.