CS 2019.02.01.14 - Bionatura https://www.revistabionatura.com/cs-2019.02.01.14.html[30/04/2020 12:03:31] CS 2019.02.01.14 Bionatura Conference Series Vol 2. No 1. 2019 “Breaking Paradigms: Towards a Multi-, Inter- and Transdisciplinary Science” In commemoration of the 250th Anniversary of Alexander von Humboldt REVISION/REVIEW General Approach to Drug Delivery Systems (DDS) Danna Belén Castillo, 1 and Hortensia Rodriguez. 1 available in: http://dx.doi.org/10.21931/RB/CS/2019.02.01.14 ABSTRACT The field of drug discovery drives to find out efficient, selective, stable and biocompatible new drugs. The purpose of drug delivery systems (DDS) is to reduce the side effects that treatments usually cause to mitigate some diseases, especially cancer. Cancer treatments are usually so strong and invasive that they end up weakening the patient, so the cure became as dangerous as the disease. That is the reason that DDS try to maximize the effectiveness of the drugs administered by wanting them to reach specifically to the area affected by the disease (High specificity). In this regard, the fruitfully use of liposome-, erythrocytes-, nanoparticles- or antibodies-based therapies became a choice for the treatment of a huge range of diseases, due to the biocompatibility that these macromolecular systems present. In the last five years, a broad range of DDS have been developed, and some of them, specifically four ADC´s are approved by the FDA and commercializing. In this work, we summarized the most important approach to DDS obtained through chemical conjugation, highlighting ADC´s like the most promising controlled release systems. keuword: Drug delivery systems, Nanocarriers, Biocarriers, therapeutic agents, Antibody Drug Conjugates. INTRODUCTION Drug discovery field drives to find out efficient, selective, stable and biocompatible new drugs, also looking for avoiding side effects. Current advances in the mechanistic understanding of the molecular drivers of malignancy have led to many new drugs, which are targeted directly at the malignant cells or therapeutic targets, and not the neighbouring healthy cells. Thus, in order to enhance the efficacy of existing drugs or therapies, several drug delivery approaches have been developed. Bionatura Index Files Editorial Team Instructions Policies Contacts Online first Latin American Journal of Biotechnology and Life Sciences