_____________________________________________________________________________________________________ *Corresponding author: E-mail: ramisalama2020@gmail.com; Journal of Advances in Medicine and Medical Research 34(23): 122-128, 2022; Article no.JAMMR.92502 ISSN: 2456-8899 (Past name: British Journal of Medicine and Medical Research, Past ISSN: 2231-0614, NLM ID: 101570965) Congenital Diaphragmatic Hernia: A Review of Its Management Rami M. Salama a* , Hisham A. Almetaher a , Ashraf A. Elattar a , Hisham F. Fayad a and Sherif M. Shehata a a Section of Pediatric Surgery, Tanta University Hospital, University of Tanta, 31512 Tanta, Al-Geish St., Egypt. Authors’ contributions This work was carried out in collaboration among all authors. All authors read and approved the final manuscript. Article Information DOI: 10.9734/JAMMR/2022/v34i234845 Open Peer Review History: This journal follows the Advanced Open Peer Review policy. Identity of the Reviewers, Editor(s) and additional Reviewers, peer review comments, different versions of the manuscript, comments of the editors, etc are available here: https://www.sdiarticle5.com/review-history/92502 Received 15 August 2022 Accepted 20 October 2022 Published 31 October 2022 ABSTRACT Congenital Diaphragmatic Hernia (CDH) is considered a defect in diaphragm development which occurs congenitally, its incidence is about 1 in 2500 newborns. Major components of CDH are increased pulmonary pressure with fetal circulation persistence, with significant reduction in lung compliance and its tidal volume. Preoperative stabilization and optimization should preceed the surgical repair which is done usually via laparotomy which is considered to be the standard approach. Minimally invasive procedures for CDH repair provides the patient with the benefit of less pain and avoidance of the consequences of thoracotomy or laparotomy compared with the open repair strategy, inspite of prescence of disadvantages mainly from insufflation and CO 2 absorption, but this can be controlled with lower CO 2 pressure, better insufflation instruments and continuous monitoring of blood gases. Keywords: Congenital diaphragmatic hernia; abnormal pathophysiology; laparotomy; thoracotomy; surgical repair. Review Article