Pharmacologyonline 1: 409-421 (2008) Saha et al. 410 ANTIDIABETIC AND ANTIOXIDANT ACTIVITY OF METHANOL EXTRACT OF IPOMOEA REPTANS POIR AERIAL PARTS IN STREPTOZOTOCIN INDUCED DIABETIC RATS Prerona Saha * , V.Thamil Selvan, Susanta Kumar Mondal, U.K.Mazumder, M.Gupta. Department of Pharmaceutical Technology, Jadavpur University, Kolkata-700032, India. * Corresponding Author’s contact id: prerona_saha@rediffmail.com Summary Diabetes mellitus is a metabolic disorder characterized by fast elevation of blood sugar level, along with other multiple complications and is a growing health concern worldwide. The present study was undertaken to evaluate the antihyperglycemic activity of methanol extract of aerial part of Ipomoea reptans Poir (Convolvulaceae) in streptozotocin (STZ) induced diabetic rats. After 14 days treatment with the methanol extract, 200 and 400 mg/kg b.wt. p.o., fasting blood glucose (FBG) level was found to be reduced by 56.16% and 65.7% respectively with respect to the initial FBG levels. Antioxidant activity of the extract was determined by measuring MDA, Catalase and glutathione (GSH) levels of liver, kidney and pancreas tissues. Apart from these, body weight, serum enzyme levels (SGPT, SGOT, ALP), total protein, triglyceride and total cholesterol level were also estimated. Results of the extract treated groups were compared with those of the diabetic control and normal animals. For all the estimated parameters, the results of the extract treated groups were restored to the near normal level, thereby indicating good antihyperglycemic and antioxidant activity of the methanol extract of I. reptans. Key words: Ipomoea reptans, Diabetes, Streptozotocin, Antihyperglycemic.