Abstract Context: The novel coronavirus named as COVID-19 (SARS-CoV-2) from its origin in Hubei spread across the continent in a short period of six months’ time. Till date there is no drug to cure the novel corona virus SARS-CoV-2. Earlier studies on SARS-CoV-1 suggests that interleukin 6 (IL-6) and Interleukin 8 (IL-8) were in the higher levels indicating the key role of IL. Aim: Molecular simulation studies were carried out on the selected 24 chemical constituents present in rasam against IL-6 to identify the key interaction between the amino acid residues and their chemical structure Materials and Methods: A library of 24 chemical constituents was sketched using Chem Sketch programming 8.0. The 3D structures of ligands were retrieved in mol format in Maestro v 11.3 and the ligands were optimized utilizing ligprep (4.3) module (Schrödinger 2018-1). Results: One of the chemical constituents sinigrin a glucosinolate emerged as top scorer with a GLIDE score of -6.333. It was apparent from the examination, that the Van der Waals (∆G bindvdW) and coulomb energy interactions were major great contributors. The structural diversity of sinigrin from the rest of other chemical constituents in rasam led to significantly better interaction with amino acid residues. Conclusion: The study identifies sinigrin, as one of the active constituents in rasam possessing good binding affinity against IL-6 which can be used as a dietary supplement and can be used as a control measure to fight against Covid-19. *Author for correspondence JOURNAL OF NATURAL REMEDIES DOI: 10.18311/jnr/2021/28191 Article Received on: 13.07.2021 Accepted on: 07.09.2021 Revised on: 09.08.2021 Keywords: Functional Food, IL-6 Inhibitor, SARS-CoV-2, Sinigrin, Tartaric Acid 1. Introduction Te novel coronavirus named as COVID-19 (SARS- CoV-2) from its origin in Hubei spread across all the continent in a short period of six months’ time 1 . Tough a wide range of potent antiviral drugs are available, WHO concluded that none of the drugs can prevent or cure 100 % SARS-CoV-2 till date. However, discovery of newer drug molecules or drug repurposing and the development of vaccine can help us in the treatment or prevention of this viral infection. Te developments of drugs or vaccines may require months or even years to prove its efcacy to control SARS-CoV-2. Hence, researchers all over the world have started In silico screening of a series of small molecules inhibitors either from the available chemical database or natural compounds, drug repurposing to directly inhibit the key proteins in SARS-CoV-2. Interleukin 6 (IL-6) is a soluble mediator that acts as pro infammatory cytokines and is made up of 212 amino acids with core protein glycosylation accounts for the size of 21–26 kDa 2 . Te signifcant role of cytokines in various diseases including cancer is well documented 3–5 . In silico Screening of Chemical Constituents in Rasam as a Benefcial Supplementary Treatment for Novel Coronavirus M. K. Mohan Maruga Raja 1 , Jubie Selvaraj 2 , S. S. Pottabathula 2 , G. V. Anjana 3 and M. K. Kathiravan 3* 1 Department of Pharmacognosy and Phytochemistry, Parul Institute of Pharmacy and Research, Parul University, Vadodara, Gujarat – 391760, India 2 Department of Pharmaceutical Chemistry, J.S.S. College of Pharmacy, Udhagamandalam, Tamil Nadu – 643001, India 3 Dr. APJ Abdul Kalam Research Laboratory, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu – 603203, India; drmkkathir@gmail.com SHORT COMMUNICATION