Quarterly Journal of Psychological Methods and Models Fall 2021. Vol 12. Issue 45 Research Paper Comparison of the effectiveness of motivational interviewing and matrix treatment with Cognitive- Behavioral Approach on depression and quality of life in marijuana users Abdul Rasoul Kaviyani 1 , Hojjatullah Javid 2* , Hossein Baghooli 3 , Majid Barzegar 4 1. Ph.D. Student in General Psychology, Department of Consulting, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran 2. * Department of Consulting, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran 3. Department of Consulting, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran 4. Department of Consulting, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran Received: 2020/10/29 Revised: 2021/09/09 Accepted: 2021/10/12 Abstract Introduction: Drug addiction is associated with a wide range of diseases, disorders and disabilities. The purpose of this study was to compare the effectiveness of motivational interviewing and matrix treatment with Cognitive-Behavioral Approach on depression and quality of life in marijuana users. Method: Experimental research method along with pretest- posttest design used with three groups (two experimental groups, a motivational interviewing group, a matrix treatment group and a control group). The statistical population was all marijuana addicts in Shiraz. Statistical samples were selected from marijuana addicts referred to Mehrari Hospital in Shiraz. Individuals were randomly assigned to three groups (15 people in each group). Weir Scherborn quality of life Scale and Beck Depression were used to collect data. Results: The results showed that matrix treatment and motivational interviewing were significantly different from the control group, but matrix treatment with motivational interviewing were not different in effectiveness. Conclusion: Based on the findings of the present study, it can be concluded that both therapies can be used as adjunctive therapies in marijuana addicts. Use your device to scan and read the article online DOI: 10.30495/jpmm.2021.26416.3227 Keywords: Motivational interviewing, matrix treatment with Cognitive- Behavioral Approach , depression, quality of life , marijuana users Citation: Kaviyani AR, Javid H, Baghooli H, Barzegar M. Comparison of the effectiveness of motivational interviewing and matrix treatment with Cognitive-Behavioral Approach on depression and quality of life in marijuana users. Quarterly Journal of Psychological Methods and Models. 2021; 12 (45): 35-48. *Corresponding author: Hojjatullah Javid Address: Department of Consulting, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran. Tell: 09171130190 Email: Javid952@hotmail.com