Recent Progress in Medicinal Plant (2006) 1 Antioxidant Activity of Cinnamtannin B1 from Cinnamomum zeylanicum BLUME M.Taher a *, Deny Susanti b , Mohamad Roji Sarmidi a , Fadzilah Adibah Abdul Majid a , Hasnah M. Sirat b and Farediah Ahmad b a Department of Bioprocess, Faculty of Chemical and Natural Resources Engineering, Universiti Teknologi Malaysia, 81310, Skudai, Johor, Malaysia b Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, 81310 Skudai, Johor, Malaysia Abstract Antioxidative activity of cinnamtannin B1 from Cinnamomum zeylanicum Blume was investigated. Antioxidants assay were carried out using lipid peroxidation by ferric thiocyanate (FTC) and DPPH radical scavenging analyzed with ultraviolet spectroscopy and electron spin resonance spectroscopic methods. Cinnamtannin B1 exhibited antioxidant activity in a series of in vitro test. It was found to be active inhibit lipid peroxidation in ferric thiocyanate method. It was also active scavenged the radical 1,1-diphenyl-2- picrylhyrazyl which was analyzed with ultraviolet and electron spin resonance spectrometer with IC 50 of 36 mM and 0.2 µM respectively. Key words: Cinnamomum zeylanicum; proanthocyanidin; cinnamtannin B1; antioxidants activity 1. Introduction Flavonoids occur in the most plant species, concentrating in seeds, fruit skin or peel, bark and flowers. Flavonoids have been found to have antioxidative, antimicrobial, enzyme-inhibiting, antitumor and antimutagenicity, antiinflamatory activity [1, 2]. Flavonoids are group of compounds characteristic by a C6-C3-C6 configuration and can participate in hydrogen donating, radical scavenging and metal chelating mechanisms [3]. brought to you by CORE View metadata, citation and similar papers at core.ac.uk provided by Universiti Teknologi Malaysia Institutional Repository