145 Summer 2021. Volume 2. Number 3 Mehdi Badkoubeh Hazaveh 1 , Bahram Abedi 1* , Saleh Rahmati Ahmadabad 2 1. Department of Physical Education, Mahallat Branch, Islamic Azad University, Mahallat, Iran. 3. Department of Physical Education, Pardis Branch, Islamic Azad University, Pardis, Tehran, Iran. * Corresponding Author: Bahram Abedi, PhD. Address: Department of Physical Education, Mahallat Branch, Islamic Azad University, Mahallat, Iran. Phone: +98 (918) 8667662 E-mail: abedi@iaumahallat.ac.ir Research Paper Efect of Aerobic Exercises on Reduced and Oxidized Glutathione in Aortic Endothelial Cells of Rats Exposed to Arsenic Background and Aim: Arsenic is an environmental pollutant that can damage tissue by producing free radicals. However, regular aerobic exercise is essential in enhancing antioxidant defense and resisance to oxidative sress. This sudy aimed to evaluate the efect of aerobic exercise on reduced glutathione (GSH) and oxidized glutathione (GSSG) and aortic endothelial cells of of heart tissue in rats exposed to arsenic. Materials and Methods: In this experimental sudy, 24 male Wisar rats with a weight ranged 220-240 g and a mean age of 6-8 weeks were divided into 3 groups of 8: healthy control, toxic control, and toxic aerobic exercise. Rats receiving arsenic were prescribed 25 ppm arsenic daily in oral water for 8 weeks. The exercise program consised of 8 weeks of aerobic exercise, fve sessions per week with an intensity of 75%-80% of maximum oxygen consumption. Eventually, 24 hours after the las exercise session, the rats were aneshetized and killed, and the target tissue was removed for examination. The Kolmogorov-Smirnov satisical tes and one-way analysis of variance with Tukey pos hoc tes were used to analyze the fndings in SPSS software, version 22 (P≥0.05). Results: Exposure to arsenic signifcantly reduced GSH and GSSG levels in heart tissue and aortic endothelial cells (P≥0.05). In contras, aerobic exercise increased GSH and GSSG levels in heart tissue and aortic endothelial cells in arsenic-poisoned rats (P≥0.05). Conclusion: Aerobic exercise efectively reduces oxidative sress and increases antioxidant defense agains arsenic toxicity in heart disorders. A B S T R A C T Keywords: Exercise, Glutathione resuscitation, Glutathione, Glutathione oxide, Arsenic Please cite this article as Badkoubeh Hazaveh M, Abedi B, Rahmati Ahmadabad S. Efect of Aerobic Exercises on Reduced and Oxidized Glutathione in Aortic Endothelial Cells of Rats Exposed to Arsenic. Journal of Vessels and Circulation. 2021; 2(3):145-150. http://dx.doi.org/10.32598/JVC.2.3.93.1 http://dx.doi.org/10.32598/JVC.2.3.93.1 Use your device to scan and read the artcle online Article info: Received: 05 Sep 2021 Accepted: 25 Sep 2021 Publish: 01 July 2021