185 Corresponding author: Musa GENÇCELEP Van Yüzüncü Yıl Üniv., Veteriner Fak., Cerrahi AD, Van, Türkiye. e-mail: musacelep@yahoo.com Van Vet J, 2018, 29 (3) 185-187 Van Veterinary Journal http://dergipark.gov.tr/vanvetj ISSN: 2149-3359 Case Report e-ISSN: 2149-8644 First Case Report of Recurrent Idiopathic Calcinosis Circumscripta in a Kangal Dog in Turkey: Clinical, Radiographic and Histopathological Observations Musa GENÇCELEP 1 Serkan YILDIRIM 2 Yağmur KUŞÇU 1 1 Van Yuzuncu Yil University, Faculty of Veterinary Medicine, Department of Surgery, Van, Turkey 2 Atatürk University, Faculty of Veterinary Medicine, Department of Pathology, Erzurum, Turkey Received: 25.07.2018 Accepted: 16.12.2018 ABSTRACT A 6 months old, male, 51 kg, Kangal race dog brought to Van Yuzuncu Yil University, Faculty of Veterinary Medicine, Department of Surgery constitutes the material of this case report. In patient’s history, decreased appetite, stiff gait and lameness was reported. In clinical examination, hard, limited and painless swellings in both lateral side of tarsal joints were determined. In radiographic examination, presence of opaque areas in the masses were observed. Vicious and white fluid discharged was observed in operation. In histopathological examination, calcinosis circumscripta was determined. After 4 months, patient was brought to the clinic because of recurrent swelling in the same area. Histopathology results were the same again. It was concluded that the disorder was present in the idiopathic form. It is thought that this case should be considered important, because there is no report regarding the Kangal dogs and any presence of recurrence in the literature. Keywords: Calcinosis circumscripta, Dog ÖZ Türkiye’de Bir Kangal Köpeğinde İlk Kez Karşılaşılan Tekrarlayan Özellikteki İdiyopatik Kalsinozis Sircumskripta: Klinik, Radyografik ve Histopatolojik Gözlemler Bu olgu sunumunun materyalini Van Yüzüncü Yıl Üniversitesi Veteriner Fakültesi Cerrahi Anabilim Dalı'na getirilen 6 aylık, 51 kg ağırlığında, erkek, Kangal ırkı köpeği oluşturmaktadır. Hastanın öyküsünde, iştah azalması, tutuk yürüyüş ve topallık bildirilmiştir. Klinik muayenede, tarsal eklemlerin her iki lateralinde sert, sınırlı ve ağrısız şişlikler tespit edildi. Radyografik incelemede kitlelerde opak alanların varlığı gözlendi. Operasyonda viskoz ve beyaz renkli sıvı gözlendi. Histopatolojik incelemede kalsinozis circumscripta olduğu tespit edildi. Dört ay sonra aynı bölgede tekrarlayan şişlik nedeniyle hasta tekrar kliniğe getirildi. Nüks materyalinin histopatoloji sonuçları aynı özellik göstermekteydi. Bozukluğun idiyopatik formda olduğu sonucuna varıldı. Literatürde Kangal ırkı köpeklerde herhangi bir rapora rastlanılmamış olması ve nüks olayının gözlenmesi klinik açıdan önemli bulundu. Anahtar Kelimeler: Kalsinozis sirkumskripta, Köpek INTRODUCTION Calcinosis circumscripta is an ectopic mineralization syndrome in soft tissues, characterized by a tumor-like growth and local accumulation of calcium salts (O’Brien and Wilkie 2001; Szczepaniak et al. 2008; Tafti et al. 2005). The focal mineralized lesions are most frequently located in the region of extremity joints and subcutaneous tissues. Other sites such as mouth, gingiva, frenulum of the tongue, salivary glands, pinna, mandible, throat region and chest predispose other places where these lesions may develop (Howell and Ishmael 1968; Szczepaniak et al. 2008). Rarely, these pathological lesions can be formed in the intestines (Engel et al. 2014). This syndrome is most commonly found in large dog breeds and in younger dogs (particularly < 2 years of age), although dogs of all ages can be affected. German and Hungarian shepherd dogs are predisposed. There is no predisposition according to gender (Tafti et al. 2005; Yumuşak et al. 2014). Calcinosis circumscripta, which is not fully explained by ethiopathogenesis, is examined in its 4 forms (Szczepaniak et al. 2008). Metastatic calcification: Secondary mineralized local areas are formed due to disorders in serum calcium and phosphor levels in both humans and animals (Szczepaniak et al. 2008). The most common cause of metastatic calcinosis cutis in dogs is overproduction of adrenal hormones (corticosteroids or steroids). This may be due to cancer or overgrowth of the pituitary or adrenal glands. In some susceptible dog breeds, it may also progress from steroid hormones that are used for therapy (Ferguson 1996).