Biosaintifika 10 (1) (2018) 223-228 Biosaintifika Journal of Biology & Biology Education http://journal.unnes.ac.id/nju/index.php/biosaintifika Histology Structure of Lymph and Uterus of White Rat (Rattus nor- vegicus) Given with Nanas Bongsai (Ananas comosus var. microstachys L.)  Fitmawati 1 , Agus Saputra 1 , Yohanes 2 , Hilwan Yuda Teruna 3 , Dimas Pramita Nugraha 4 ,Yulis Hamidi 4 DOI: 10.15294/biosaintifika.v10i1.13596 1 Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Riau Kampus, Indonesia 2 Public Health Official, Riau Province, Indonesia 3 Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Riau, Indonesia 4 Department of Medical, Faculty of Mendical, Universitas Riau, Indonesia Abstract Nanas Bongsai (Ananas comosus var. microstachys L.) is an amazing herb which is used in traditional medicine by local people of Muara Lembu district as a potion to reduce pain while menstruation period for a women. The present work was designed to in- vestigate its probable side effects on the histopathologic changes in limph and uterus tissues after treated with A. comosus var. microstachys L extract in female white rats. This is an experimental research consisted of five treatments and three repetitions. Treatment composed of two controls (P 0 and P + ) and given Nanas Bongsai extract with three different dosages. Histology result of lymph show that all treatments giv- en with Nanas Bongsai with three different dosages have different diameter average of white pulp and there is no significant changes with normal control. While obser- vation towards histology structure of endometrium thickness with dosage P 1 , dos- age P 2 , dosage P 3 is 206.333±33.486; 215.667±33.486; 197.667±60.871 respectively. The most thin endometrium layer found in treatment with dosage P 3 compared to control P 0 . From this study showed that there is no toxic effect on uterus and lymph function of of Nanas Bonsai (A. comosus var. microstachys L.) at different doses, so the plant is secure for consumption by the community. How to Cite Fitmawati, Saputra, A., Yohanes, Teruna, H. Y., Nugraha, D. P. & Hamidi, Y. (2018). Histology Structure of Lymph and Uterus of White Rat (Rattus norvegicus) Given with Nanas Bongsai (Ananas comosus var. microstachys L.). Biosaintifika: Journal of Biology & Biology Education, 10(1), 223-228. © 2018 Universitas Negeri Semarang History Article Received 16 November 2017 Approved 25 March 2018 Published 30 April 2018 Keywords Nanas Bongsai (Ananas comosus var. microstachys L.); White rat (Rattus norvegicus); Lymph; Uterus  Correspondence Author: Jl. HR. Soebrantas Km 12.5 Pekanbaru 28293, Riau, Indonesia E-mail: fitmawati2008@yahoo.com p-ISSN 2085-191X e-ISSN 2338-7610