ISSN 0975-8437 INTERNATIONAL JOURNAL OF DENTAL CLINICS 2011:3(1):29-33 ©INTERNATIONAL JOURNAL OF DENTAL CLINICS VOLUME 3 ISSUE 1JANUARY-MARCH 2011 29 Incidence of Diabetes Mellitus in Patients with Lichenplanus Syeda Arshiya Ara, Mamatha G.P, B. Balaji Rao Abstract Aims: To find out the incidence of diabetes mellitus in patients with oral lichen planus (OLP). Materials and Methods: Experimental group consists of 50 OLP subjects and control group comprised of 10 subjects. Incisional biopsy from the lesion site was obtained for experimental subjects and normal oral mucosa in the third molar region was used as biopsy specimen for control subjects. Oral glucose tolerance test (OGTT) was done for all the subjects and results were tabulated and subjected to t test for analysis. Results: The OGTT for control group in fasting level, 1 and 2 hours after glucose administration were within the physiological limits in males and females. Among the 50 OLP subjects 5 (10%) were diabetic in the age range of 42-40 with a mean of 56.5 years. The results are statistically highly significant with P value of <0.001 for FBS, 1 hour and 2 hour samples when OGTT values in OLP diabetics v/s controls are compared. Key Words: Lichen Planus;DiabetesMellitu;Immunological Diseases. Received on: 12/11/2010 Accepted on: 12/01/2011 Introduction Many research works are now producing evidence that systemic diseases influences the metabolism of hard and soft tissues of oral cavity. Halevy S. And Feuerman E.J. (1979) in the study of abnormal glucose tolerance associated with lichen planus supported the possibility that, lichen planus and disorder of carbohydrate metabolism could be related.(1) Histo-biochemical studies of the affected epidermal cells in cases of lichen planus have also shown abnormalities in the enzyme activity as well as defective carbohydrate expression which might have a connection with hormones essential for the metabolic process.(2) This study was conducted a) to find out the incidence of diabetes mellitus in patients with OLP, b) to correlate any associations that may exist between OLP and diabetes mellitus, and c) to compare the incidence of glucose tolerance of controls and OLP patients. The main objective of this paper was to exclude diabetes mellitus in OLP cases, to suspect OLP in all diabetes mellitus cases and to link OLP, diabetes mellitus with immunological diseases. Materials and Methods This study was conducted in the Department of Oral Medicine and Radiology, Central Laboratory Bapuji Hospital, and Department of Oral Pathology & Microbiology of Bapuji Dental College and Hospital, Davangere, India. The study population was drawn from the patients attending the out- patient Department of Oral Medicine and Radiology. They were divided into control and experimental group. Control group: The control group comprised of 10 subjects and those who fulfilled the following criteria were included in the subject group. 1) They were in the age group of 18-35 years. 2) They were of either sex 3) They were apparently healthy 4) With normal oral mucosa 5) No family history of diabetes mellitus 6) Without any oral habits. Experimental group: This group consisted of 50 subjects of OLP. Those who fulfilled the following criteria were included in the study group. 1) With features of OLP: The clinical evaluation of OLP was based on the classification that was proposed by Andreason (1968) who described six clinical forms of OLP.(3) a. Reticular-consisting of lace like keratotic lesions. b. Plaque with slightly raised white solitary lesions. c. Papular- characterized by slightly elevated white lesions approximately 0.5-1 mm in diameter. d. Atrophic- Combining erythema plus reticular keratosis e. Bullous- and f. Erosive- Manifesting small bullae and vesicles or ulceration and atrophic features respectively. 2) Patients without diabetes mellitus and without family history of Diabetes Mellitus. RESEARCH PAPER