How to Cite: Kumar, K. P., Nihal, P. ., Bandari, N., Iswariya, V. T., Rao, A. H. om P., Rana, R., & Kaushik, S. (2022). The role of lipid based nanoparticles in brain targeted drug delivery system: An overview. International Journal of Health Sciences, 6(S4), 2924–2940. https://doi.org/10.53730/ijhs.v6nS4.8628 International Journal of Health Sciences ISSN 2550-6978 E-ISSN 2550-696X © 2022. Manuscript submitted: 09 March 2022, Manuscript revised: 18 April 2022, Accepted for publication: 27 May 2022 2924 The role of lipid based nanoparticles in brain targeted drug delivery system: An overview K. Praveen Kumar Govt of NCT Delhi, DPSRU, NewDelhi Nihal. P National College of Pharmacy, Kozhikode, Kerala Neeraj Bandari Arni School Of Pharmacy, Kangra Himachal Pradesh V. T Iswariya CMR College of pharmacy, Hyderabad, Telangana A. Hari om Prakash Rao Research Scholar,Gandhi Nagar, Rushikonda, Visakhapatnam, Andhra Pradesh 530045 Ritesh Rana Himachal Institute of Pharmaceutical Education and Research (HIPER), Bela Nadaun Sumit Kaushik Faculty of Pharmacy ,Raja Balwant Singh Engineering Technical Campus, Bichpuri, Agra Abstract---Recently, targeted drug delivery systems have gained muchimportance fordeliveringmany kinds of drugs as well as imagingagents,particularly to the targetedDisease cells or tissues. The diagnosis and treatment of brain disorders is an extremely challenging task. The blood-brain barrier (BBB) is the primary obstacle in conveying the chemotherapeutic and diagnostic agents that prompt the insufficient delivery of drug at the brain-targeted site. Many drug molecules are non-soluble in aqueous systems, unable to cross BBB, or present severe side effects. Lipid-based nanoparticle (LBNP) systems represent one of the most potential colloidal carriers. They are preferred over polymeric nanoparticles due to their high stability, excellent targeting ability,increased loading capacity, non-toxicity, low production costs, and ease of preparation. Combining drug with lipid