Supporting Information Discovery of Novel GSK-3 Inhibitors with Potent in-vitro and in-vivo Activities and Excellent Brain Permeability Using Combined Ligand- and Structure-Based Virtual Screening Mohammad A. Khanfar, Ronald A. Hill, Amal Kaddoumi, and Khalid A. El Sayed* Department of Basic Pharmaceutical Sciences, College of Pharmacy, University of Louisiana at Monroe, Monroe, Louisiana 71201 * To whom correspondence should be addressed. Tel: +1 318 342 1725; Fax: +1 318 342 1737; e-mail: elsayed@ulm.edu