Hyperbranched polyester polyacids and their binary systems with surfactants for doxorubicin encapsulation Artur A. Khannanov a, * , Marianna P. Kutyreva a, ** , Nikolay A. Ulakhovich a , Alfiya R. Gataulina a , Olga V. Bondar a , Lucia Ya. Zakharova b, c , Gennadiy A. Kutyrev c a Kazan Federal University,18 Kremlyovskaya st., Kazan 420008, Russian Federation b A.E. Arbuzov Institute of Organic and Physical Chemistry of Kazan Scientific Center of Russian Academy of Sciences, 8 Arbuzov st., Kazan 420088, Russian Federation c Kazan National Research Technological University, 68 K. Marx st., Kazan 420015, Russian Federation article info Article history: Received 2 October 2015 Received in revised form 10 December 2015 Accepted 12 December 2015 Available online 13 December 2015 Keywords: Boltorn H hyperbranched polyester polyols Hyperbranched polyester polyacids Polymer/surfactant binary systems Doxorubicin Drug encapsulation abstract Doxorubicin fixation by hyperbranched polyester polyol Boltorn H acid derivatives and their binary systems in the presence of a surfactant (Brij-35, Triton X-100) was investigated. Doxorubicin fixation degree nonlinearly depends on the number of acid groups in the polyester polyacid. Polyacid/surfactant binary systems fix up to 60% of doxorubicin from the solution. © 2015 Elsevier B.V. All rights reserved. 1. Introduction There are a great number of effective drugs that are rarely used in clinical practice due to their high toxicity. The anticancer drugs are of special importance among them. Their toxicity mainly caused by their low bioavailability [1]. Therefore, the drug encapsulation systems development is one of the most popular and difficult sci- entific areas in modern medical chemistry. All currently existing targeted delivery systems can be divided into two types: delivery systems with constant and dynamic composition. The first one include targeted delivery systems based on the synthetic polymers [2], such as PAMAM [3], PEI [4], PLA [5], and natural: DNA, RNA [6]. The major advantage of polymer sys- tems with constant composition is rigid carrier-substrate bond and the consistance of composition. The drawbacks of such systems are large molecular weight and low water solubility. Systems with dynamic composition include micellar [7], liposomal [8], exosomal systems and emulsions [9]. These systems demonstrate good water solubility, but they lose effectiveness with water dilution and are difficult to remove from the body. Besides, one of the major goals of the targeted delivery systems development is the carrier and target substrate complementarity [10]. Modern carriers for targeted delivery systems should possess the following characteristics: large molecular and solubilization capacity, suitable size, modification simplicity, peculiar surface properties, targeting capacity and low toxicity [11e 13]. Den- drimers, hyperbranched polymers (HBP) and star polymers possess the abovementioned characteristics and are the most suitable for the targeted delivery systems development [14,15]. Another systems for drugs encapsulation are molecular hydro- gels, for example nanofibrous hydrogels [16]. The application of such hydrogels provides specific drugs binding [17] and the pH controlled release [18]. However, the key drawback of the encap- sulation systems based on hydrogels is the impossibility of their intravenous injection. However, star polymers do not provide firm retention of the substrate because of the excessively large distance between branches. The number of terminal groups in star polymers is lower than in dendrimers or HBPs. Solubilization of the large substrates * Corresponding author. ** Corresponding author. E-mail addresses: arthann@gmail.com (A.A. Khannanov), mkutyreva@mail.ru (M.P. Kutyreva). Contents lists available at ScienceDirect Fluid Phase Equilibria journal homepage: www.elsevier.com/locate/fluid http://dx.doi.org/10.1016/j.fluid.2015.12.023 0378-3812/© 2015 Elsevier B.V. All rights reserved. Fluid Phase Equilibria 411 (2016) 93e100