FUNCTIONAL NEURORADIOLOGY Investigation of cognitive circuits using steady-state cerebral blood volume and diffusion tensor imaging in patients with mild cognitive impairment following electrical injury Chang-hyun Park 1 & Cheong Hoon Seo 2 & Myung Hun Jung 3 & So Young Joo 2 & Soyeon Jang 4 & Ho Young Lee 4 & Suk Hoon Ohn 4 Received: 4 May 2017 /Accepted: 28 June 2017 # Springer-Verlag GmbH Germany 2017 Abstract Purpose We utilized cerebral blood volume (CBV) magnetic resonance imaging and diffusion tensor imaging (DTI) to in- vestigate changes in cognitive networks in patients experienc- ing cognitive dysfunction following electrical injury. Methods Cognitive function was assessed across various do- mains, including attention, verbal memory, executive func- tion, and language. Depressive symptoms were also evaluat- ed. CBV maps and DTI measures were obtained from 24 patients (age, 41.8 ± 5.8 years; education, 13.3 ± 1.9 years) and 24 healthy controls (age, 42.3 ± 2.7 years; education, 14.3 ± 1.9 years). CBV maps and DTI measures were com- pared between patients and controls, and correlations between these measures and each cognitive assessment score were examined. Results Patients exhibited lower attention, verbal memory, and executive function scores than controls (all p < 0.01). Patients also exhibited higher depression scores than controls (p < 0.01), as well as a predominant increase in CBV in the cerebellar vermis relative to that of controls (height p- < uncorrected 0.001, extent p < corrected 0.05). Correlation analyses revealed a strong association between executive function scores and CBV in the bilateral posterior cingulate cortex and left mammillary body in patients (height p- < uncorrected 0.001, extent p < corrected 0.05). There were no significant differences in DTI measures between patients and controls. Conclusion The CBV maps showed hypermetabolism in the cerebello-limbic system; DTI did not find any microstructural changes. Our results suggest that patients experiencing cogni- C-hP and CHS contributed equally to this study and are joint first authors. * Suk Hoon Ohn ohneum@gmail.com; ohnsh@hallym.ac.kr Chang-hyun Park park.changhyun@hanmail.net Cheong Hoon Seo chseomd@gmail.com Myung Hun Jung mhjung@hallym.or.kr So Young Joo anyany98@hallym.or.kr Soyeon Jang iamjjangso@gmail.com Ho Young Lee unng250@naver.com 1 Department of Psychiatry, College of Medicine, Catholic University of Korea, 222 Banpo-daero Seocho-gu, Seoul 06591, Republic of Korea 2 Department of Physical Medicine and Rehabilitation, Hangang Sacred Heart Hospital, Hallym University College of Medicine, 12 Beodeunaru-ro 7 Gil Yeongdeungpo-gu, Seoul 07247, Republic of Korea 3 Department of Psychiatry, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, 22 Gwanpyeong-ro 170 Beon-gil, Dongan-gu Anyang, Gyeonggi-do 14068, Republic of Korea 4 Department of Physical Medicine and Rehabilitation, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, 22 Gwanpyeong-ro 170 Beon-gil, Dongan-gu Anyang, Gyeonggi-do 14068, Republic of Korea Neuroradiology DOI 10.1007/s00234-017-1876-1