1 Functionalization of additive-manufactured Ti6Al4V scaffolds with poly(allylamine hydro- chloride)/poly(styrene sulfonate) bilayer microcapsule system containing dexamethasone Ekaterina Chudinova 1 , Andrey Koptyug 2 , Yulia Mukhortova 1 , Artyom Pryadko 1 , Anastasiya Volkova 1 , Alexey Ivanov 1 , Evgenii Plotnikov 1 , Yelena Khan 1 , Matthias Epple 3 , Viktoriya Sokolova 3 , Oleg Prymak 3 , Timothy Douglas 4,5 , Roman Surmenev 1 , Maria Surmeneva 1,* 1 Physical Materials Science and Composite Materials Centre, Research School of Chemistry & Applied Biomedical Sciences, National Research Tomsk Polytechnic University, 30 Lenin Ave- nue, Tomsk 634050, Russian Federation 2 Department of Mechanical Engineering and Quality Technology, SportsTech Research Centre, Mid Sweden University, Akademigatan 1, SE 831 25, Östersund, Sweden 3 Inorganic Chemistry and Center for Nanointegration Duisburg-Essen (CeNIDE), University of Duisburg-Essen, Essen 45117, Germany 4 Engineering Department, Lancaster University, Lancaster, United Kingdom 5 Materials Science Institute (MSI), Lancaster University, Lancaster, United Kingdom * corresponding author: surmenevamaria@mail.ru Abstract Porous titanium alloy Ti6Al4V scaffolds manufactured via electron beam melting (EBM ® ) re- veal broad prospects for applications in bone tissue engineering. However, local inflammation and even implant failure may occur while placing an implant into the body. Thus, the application of drug carriers to the surface of a metallic implant can provide treatment at the inflammation site. In this study, we propose to use polyelectrolyte (PE) microcapsules formed by layer-by- layer (LbL) synthesis loaded with both porous calcium carbonate (CaCO3) microparticles and the anti-inflammatory drug dexamethasone (DEX) to functionalize implant surfaces and achieve controlled drug release. Scanning electron microscopy indicated that the CaCO3 microparticles