Int. J. Pharm. Sci. Rev. Res., 76(2), September - October 2022; Article No. 21, Pages: 121-129 ISSN 0976 – 044X International Journal of Pharmaceutical Sciences Review and Research Available online at www.globalresearchonline.net ©Copyright protected. Unauthorised republication, reproduction, distribution, dissemination and copying of this document in whole or in part is strictly prohibited. 121 *Sunil Kumar Bishoyi 1 , Upendra Prasad Tripathy 2 & Subhransu Sekhar Gouda 3 1 Model Degree College, Rayagada, Odisha, India, 765017. 2 Pulp & Paper Research Institute, Jaykaypur, Rayagada,Odisha, India, 765017. 3 Malaviya National Institute of Technology, Jaipur, Rajasthan, India, 302017. *Corresponding author’s E-mail: sunilkumar.bishoyi3@gmail.com Received: 22-07-2022; Revised: 26-09-2022; Accepted: 05-10-2022; Published on: 15-10-2022. ABSTRACT Ethnomedicine is the branch of ethnobiology in which the relationship between the use of medicinal plants and human culture is studied. Rayagada a tribal district of Odisha has rich in tradition of conservation of nature through religious and cultural practices. Ethnomedicine concentrates the attention about plants has been used and perceived in human societies. The tribal people in Rayagada district primarily depends upon medicinal plants for curing many diseases. The present research gives a clear identification of forest area in Rayagada district by ArcGIS and from tribal forest locality 30 medicinal plants species belonging 30 families are identified. Their English name, Local name, uses and phytoconstituents are reported in a significant way. Health, life sustainability and agedness enjoyed by the tribal people have been attributed by them to these ethnomedicinal plants of Rayagada district, Odisha. Ethnomedicinal plants and other economic plant species are cultivating in locality of Rayagada district and can play a key role in the economic development of these areas. Documentation and herbarium records of traditional knowledge on the ethnomedicinal use of these plants are essential for conservation of plant resources and development of new drugs. Keywords: Ethnomedicine, Phytoconstituents, Medicine, Herbarium records, ArcGIS. QUICK RESPONSE CODE → DOI: 10.47583/ijpsrr.2022.v76i02.021 DOI link: http://dx.doi.org/10.47583/ijpsrr.2022.v76i02.021 INTRODUCTION thnobotany is the scientific study of the relationships that exist between people and plants. Ethnomedicines aim to document, describe, and explain complex relationship between their cultures and use of plants. It focuses primarily on how plants are used, managed, and perceived across human societies. Ethnomedicine encourages awareness for creating a relationship between biodiversity and cultural diversity as well as the mutual influence of medicinal plants and humans. Medicinal plants are used as traditional herbal medicines in many parts of India, out of which the tribal people of Rayagada districts, Odisha a best community depending on the medicinal plants for different disease. Medicinal plants resources have served the basic needs of humans including healthcare since ancient time. In Indian literature, ethnomedicine can be much focused in the Charak Samhita, Charak Shusruta and Vedic literature appeared as the valuable works. Reeta kumara et. al. (2013) reported on the important medicinal parameters of Rauvolfia Serpentina L. which contains alkaloids, carbohydrates, flavonoids, glycosides, phlobatannins, phenols, resins, saponin sterols, tannins & terpenes 1 . Khan H K (2009) reported that defense against diseases can be increase by using Emblica officinalis 2 . A brief review on phytochemical and pharmacological properties of Curcuma Amada is given by Mahadevi & Kavitha (2020) 3 . A substantial portion of Rayagada district was covered with forests which yields many medicinal plants. The Indigenous tribal people depend on for their clothes, shelter, food, and medicine 4-7 . In the tribal culture environmental knowledge is shared from hereditary from old people. They have a proper knowledge on natural treatment of different diseases by herbal medicine called “Ethnomedicine” or “Traditional medicine (TM) 8-10 . According to WHO, traditional medicine strategy reported that majority population in developing countries including approximately 65% of Indigenous population confidences mostly on TM for the primary health care needs 11 . WHO, Geneva reported that 80% world population use the traditional healing practices, while in India, 63% population is living in rural areas, remote areas, and forest environment, depend on T.M because T.M are safe, cost-effective and affordable 12 . About 85% of the T.M used in main health care is obtained from plant species 13 . Therefore, the main objective of this research is to documents the ethnomedicinal plant species and their Indigenous knowledge used for preparation of traditional medicines by tribal people of Rayagada district, Odisha. The main objective of the research is to examine the practices of ethnomedicine species by the local people, to create a novel documentation for the ethnomedicinal plant species in the study area and to study the belief system in the tribal community of Rayagada district against Identification of Forest by GIS and Ethnomedicinal Plant Survey in Rayagada, Odisha, India E Research Article