PROGRESS IN MEDICAL SCIENCES, 2021 VOL 5, NO. 1, PAGE 1 – 7 DOI: doi.org/10.47363/PMS/2021(5)139 Open Access RESEARCH ARTICLE A Study of Vitamin D Status in Type 2 Diabetes Mellitus and Association of Vitamin D Levels with Glycemic Control Fahmida Khatoon 1 *, Shimaa Mohammed Hasnin Aboelnaga 2 , Abdulsalam Al- Mhwes 3 , Bashir Ahmed 4 and Zahid Balouch 5 1 Associate Professor Department of Biochemistry, College of Mediciner, University of Ha’il 2 Deanship of preparatory year , University of Ha’il, Saudi Arabia 3 Doctor in Medical Clinics at the University of Hail, Ha’il University Clinics, Saudia 4 Lecturer in Animal Production Department at Diary and Polytechnic Al Kharj, Saudia 5 Technician, United Medical College, Pakistan Contact Fahmida Khatoon  drfahmida24@gmail.com  Associate Professor Department of Biochemistry, College of Mediciner, University of Ha’il. © 2021 The Authors. This is an open access artcle under the terms of the Creatve Commons Atributon NonCommercial ShareAlike 4.0 (htps:// creatvecommons.org/licenses/by-nc-sa/4.0/). Introducton Type 1 DM can occur at any age. It occurs most commonly in juveniles but can also occur in adults, especially in those in their late 30s and early 40s [1]. Type 1 diabetes mellitus (DM) is a catabolic disorder in which circulatng insulin is very low or absent, plasma glucagon is elevated, and the pancreatc beta cells fail to respond to all insulin-secretary stmuli. The pancreas shows lymphocytc infltraton and destructon of insulin-secretng cells of the islets of Langerhans, causing insulin defciency. Patents need exogenous insulin to reverse this catabolic conditon, prevent ketosis, decrease hyperglucagonemia, and normalize lipid and protein metabolism [2]. One theory regarding the etology of type 1 DM is that it results from damage to pancreatc beta cells from infectous or environmental ABSTRACT Diabetes mellitus is a group of metabolic disorders, characterized by chronic hyperglycemia due to relatve or absolute defciency of insulin. There can be a defect in insulin secreton, or its acton (insulin resistance) or both. Diabetes mellitus (DM) is a worldwide health problem with rising prevalence, which seems due to change in life style, increasing obesity rates and aging of the populaton. Osteopenia and bone fragility is one of the problems faced by many diabetcs without the nature of cause of either residual insulin secreton or high insulin requirement. Studies also show that patents with type 2 diabetes (T2DM) have an increased risk of hip and vertebral fracture, thus hintng the link between the two distnct pathologies. Aim of this study is to fnd out the associaton between Vitamin D levels with glycemic Control and to measure the vitamin Levels in Diabetes Patents. Conclusion: There is Negatve associaton between Vitamin D and glycemic control. Materials & Methods: This Cross sectonal study was conducted in the Hail region, KSA, during the period of 1 st January 2018 to 21 st March 2019. Total 210 study patents aged 18– 60 years; their Vitamin D levels were estmated and their socio-demographics data were collected regarding natonality, femininity, oldness, marital status, educatonal level, and occupaton and analyze by SPSS 17. Result: Only 0.5 percent of the total sample was Vitamin D sufcient, while 37.1 percent was insufcient. Majority i.e. 62.4 % had defciency of vitamin D. It can be observed that majority of patents i.e. 53.8 % had diabetes for 5-10 years. Only 9 patents out of a total of 210 had diabetes for more than 15 years. Conclusion: levels are Vitamin D levels in Diabetc patents are found to be low in Diabetc patents. Negatve associaton is present between HbA1c levels and derangements in serum Vitamin D. ARTICLE HISTORY Received Mar 25, 2021 Accepted Apr 01, 2021 Published Apr 10, 2021 KEYWORDS Diabetes Mellitus, Vitamin D: BMI, HbA1c