www.wjpps.com Vol 6, Issue 6, 2017. 436 Sumathy et al. World Journal of Pharmacy and Pharmaceutical Sciences AN OVERVIEW OF COMPARTIVE STUDY OF PYRAZOLE AND PYRIMIDINE DERIVATIVES Sumathy Arunachalam*, Dr. N. L. Gowrishankar, Ankitha Krishnan, Archana Akhileswaran and Tindu K D Prime College of Pharmacy, Prime Nagar, Erattayal, Palakkad, Kerala 678551. ABSTRACT Pyrimidine and pyrazole shows various pharamacological activities. Pyrimidine is a heterocyclic aromatic organic compound containing two nitrogen atoms at positions 1 and 3 of the six-membered ring which shows wide range of biological activities. [1] Pyrimidines are synthetically versatile substrates, where they can be used for the synthesis of a large variety of heterocyclic compounds and as raw material for drug synthesis. It was therefore the objective of this review to systematically evaluate the pharmacological properties of various substituted pyrimidine and collate these findings to be used as a guide for future structure-activity relationship and mode of action studies. [2] Pyrazoles are an important class of five membered heterocyclic compounds; are widely found as the core structure in a large variety of compounds that possess important agrochemical and pharmaceutical activities. [3] The main aim of this review is the comparative study of pyrazole and pyrimidine. KEYWORD: pyrimidine, pyrazole, pharmacological activities, versatile, core structure. INTRODUCTION Both pyrimidine and pyrazole are heterocylic compounds. Both have many pharmacological activities. Pyrimidines are the heterocyclic aromatic compounds similar to benzene and pyridine containing two nitrogen atoms at positions 1 and 3 of the six membered rings. [4,5] Heterocycles containing pyrimidine moiety are of great interest because they constitute an important class of natural and nonnatural products, many of which exhibit useful biological activities and clinical applications. [6-8] The chemistry of heterocyclic compounds is the most WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES SJIF Impact Factor 6.647 Volume 6, Issue 6, 436-446 Review Article ISSN 2278 – 4357 Article Received on 25 March 2017, Revised on 14 April 2017, Accepted on 04 May 2017 DOI: 10.20959/wjpps20176-9251 *Corresponding Author’ SumathyArunachalam Prime College of Pharmacy, Prime Nagar, Erattayal, Palakkad, Kerala 678551.