Plant Science Today, ISSN 2348-1900 (online) OPEN ACCESS ARTICLE HISTORY Received: 30 April 2022 Accepted: 05 July 2022 Available online Version 1.0 : 28 August 2022 Additional information Peer review: Publisher thanks Sectional Editor and the other anonymous reviewers for their contribution to the peer review of this work. Reprints & permissions information is avail- able at https://horizonepublishing.com/ journals/index.php/PST/open_access_policy Publisher’s Note: Horizon e-Publishing Group remains neutral with regard to jurisdic- tional claims in published maps and institu- tional afiliations. Indexing: Plant Science Today, published by Horizon e-Publishing Group, is covered by Scopus, Web of Science, BIOSIS Previews, Clarivate Analytics, NAAS etc. See https://horizonepublishing.com/journals/ index.php/PST/indexing_abstracting Copyright: © The Author(s). This is an open- access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited (https://creativecommons.org/licenses/ by/4.0/) CITE THIS ARTICLE Osman MFA, Abdalla SS, Abdelghani S, Mangi AA, Eltayeb LB. Anti-bacterial potential of (Acacia nilotica, Trigorella foeum-graecum, Punica granatum and Commiphora myrrha) crude extracts against diverse drug sensitive and resistant bacterial species. Plant Science Today (Early Access). https://doi.org/10.14719/pst.1874 Abstract The alarming increase in bacterial resistance to antibiotics caused some authors to state that we are approaching a post-antibiotic era and medical catastrophe, the study aimed to assess the antimicrobial efects of selected plant extracts against several sensitive and resistant bacterial isolates. Ex- perimental cross-sectional study was conducted, 70% ethanol crude Acac- cia nilotica, Trigonella foenum-graecum, Punica granatum and Commiphora myrrha extract was prepared and several commercial antimicrobials agent tested, the antibacterial activity was investigated using the disc difusion method. The inhibition zones' diameters (mm) were calculated and inter- preted by Zone Diameter Interpretative Standards. Data were analyzed by using (SPSS) sofware version 22. About 200% of A. nilotica and T. foenum- graecum showed bactericidal efects against Enterococcus faecalis, means ±SD (12.3 ± 2.8 and 12.5 ± 2.1). The activity of 200% C. myrrha extract was highest against all diverse bacterial. Despite a relatively high inhibition zone among all plant ethanol extracts, the findings demonstrate that there is no statistical significance in the inhibitory activity impact of varying concentra- tions of 70% ethanol extracts of all plants extract against bacterial isolates (P. value ≥ 0.05). The outcomes of the ethanol extracts of the used plant un- der study demonstrated that the herbal extract can be a superior antimicro- bial potential than the result of the commercial broad spectrum antimicro- bial agent utilized. C. myrrha extract was potent antimicrobial activity against all diverse bacterial species. Keywords Plant extract, antimicrobial efects, bacterial species, multi-drug resistant Introduction Acacia nilotica is a common herb that is found in tropical and subtropical areas. Traditional ayurvedic global best practices using A. nilotica leaves, bark and pods to treat cancer, cough, gastroenteritis, pyrexia, small pox, piles and menstrual cramps. It is also confirmed to have antimicrobial prop- erties wide range of gram positive and gram-negative bacteria and fungi (1). T. foenum-graecum, also known as fenugreek, is among the ancient thera- peutic plants, with various potential health benefits including hepatopro- tective, anti-inflammatory, antiulcer, antilithigenic, antitumor, antimicrobi- al and neuroprotective efects (2). P. granatum, also widely recognized as RESEARCH ARTICLE PLANT SCIENCE TODAY ISSN 2348-1900 (online) Vol x(x): xx–xx https://doi.org/10.14719/pst.1874 HORIZON e-Publishing Group Anti-bacterial potential of (Acacia nilotica, Trigonella foenum- graecum, Punica granatum and Commiphora myrrha) crude extracts against diverse drug sensitive and resistant bacterial species Meaad Fakhraldeen Abdalla Osman 1 , Sababil Salih Abdalla 1 , Sara Abdelghani 2 , Altaf Ali Mangi 3 & Lienda Bashier Eltayeb 4* 1 Department of Microbiology, Faculty of Medical Laboratory Sciences National University -Khartoum, 11115, Sudan 2 Department of Parasitology, Faculty of Medical Laboratory Sciences, Al Neelain University, Khartoum, 11115, Sudan 3 Faculty of Pharmacy Gomal University Dera Ismail Khan Khyberpakhunkhaw, 29111, Pakistan 4 Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Alkharj, 11942, Saudi Arabia *Email: lindarose009@hotmail.com