The Effects of Glibenclamide on Serum Lipids and Lipoproteins in Type II Non-Insulin Dependent Diabetes Mellitus Pages with reference to book, From 89 To 92 Muhammad Azhar Mughal,Kausar Aamir,Mehar Ali ( Departments of Pharmacology, Therapeutics Basic Medical Sciences Institute, Jinnah Postgraduate Medical Centre, Karachi. ) Wali Muhammad Maheri ( Departments of Physiology, Basic Medical Sciences Institute, Jinnah Postgraduate Medical Centre, Karachi. ) Muhammad Jan ( Department of Pharmacology, Khyber Medical College, Peshawar. ) Abstract Objective: To examine the effects of glibenclamide treatment on plasma lipids and lipoprotein levels. Settings: Out patients of Type II diabetics from department of Baqai Diabetes and Endocrine Centre and two other diabetic clinics of Karachi. Methods: The effects of glibenclamide on blood glucose and various aspects of lipoproteins has been studied in 26 (14 male, 12 female) Type II Diapetes patients before and after 12 weeks of glibenclamide therapy. Treatment was initiated with 5 mg oral glibenclamide with diet control. The initial dosage of glibenclamide was 5 mg/day taken half an hour before meal; this was increased to 5 mg per week and was adjusted according to the patient’s tolerance to the drug and their glycemic control. Results: The results demonstrated that fasting blood glucose declined from 221.53+7.84 to 165.02+5.12 mg/dl, (P<0.001). There was a statistically significant increase in the plasma high-density lipoprotein cholesterol from 33.60+1.00 to 37.07+1.05 mg/dl, (P<<0.05). Total cholesterol, triglycerides, low-density lipoprotein cholesterol and very-low-density lipoprotein cholesterol did not change significantly. Conclusion: Improved glycaemic control in patients treated with glibenclamide with Type II Diabetes was achieved which lead to changes in lipoprotein metabolism. There was no evidence of changes in lipoproteins in. directions associated with an increased risk for atherosclerosis OPMA 49: 89, 1999). Introduction Subjects with type II diabetes are characterized by a very high cardiovascular morbidity and mortality rate. Plasma lipoprotein abnormalities of concentration, composition, or subfraction distribution are one of the main factors for the enhanced cardiovascular risk 1 . The major cause of morbidity and mortality of patients with diabetes is macrovascular disease. The mechanisms by which diabetes accelerates atherosclerosis are not well understood. One of the significant risk factors for atherosclerosis in the diabetic population is dyslipidemia 2 . Moreover, it is well known that blood glucose optimization (reached by diet, hypoglycemic drugs, or insulin therapy) influences lipoprotein metabolism positively in Type II diabetic patients, although a complete normalization in plasma lipoprotein concentration and composition abnormalities is seldom obtained with this type of diabetes 1-3 . Lipoprotein abnormalities in Type II patients involve all classes of lipoprotein and may consist of chylomicronemia, high levels of very-low density lipoprotein (VLDL) and low-density lipoproteins (LDL) 4 . Also elevated triglycerides levels are commonly seen in type II diabetic subjects 5 . Low concentrations of High Density Lipoprotein (HDL) cholesterol appear to be an outstanding lipoprotein predictor of cardiovascular diseases. The true nature of the relationship between diabetic conditions and increased Coronary Artery Disease (CAD) still remains unclear and