ISSN: 2277- 7695 CODEN Code: PIHNBQ ZDB-Number: 2663038-2 IC Journal No: 7725 Vol. 1 No. 8 2012 Online Available at www.thepharmajournal.com THE PHARMA INNOVATION Vol. 1 No. 8 2012 www.thepharmajournal.com Page | 43 Improvement In Taste And Solubility Of Atenolol By Solid Dispersion System Soniya Madaan* 1 , Atul Kumar Gupta 2 , Vipin Sardana 3 1. B.S. Anangpuria College of Pharmacy, Alampur (Faridabad), India 2. Maharishi Markendeshwar College of Pharmacy, Mullana (Ambala) , India 3. G.V.M. College of Pharmacy, Sonepat, Haryana, India Work Affiliation- Maharishi Markendeshwar College of Pharmacy, Mullana (Ambala) The aim of this study was to mask the bitter taste of Atenolol along with solubility enhancement by solid dispersion system. Solid dispersions were prepared by the solvent evaporation method using β-cyclodextrin. The solid dispersion of atenolol with β-cyclodextrin was evaluated by Differential scanning colorimeter (DSC), Scanning electron microscopy (SEM). The taste masking property of solid dispersions in different ratio combination of Atenolol with β- cyclodextrin was evaluated on human volunteers. The influence of different ratio of carrier on solubility of drug was also evaluated. Solid dispersion at ratio 1:3 w/w completely masks the bitterness of Atenolol. The solubility and dissolution rate of Atenolol was significantly increased by solid dispersion as well as by their physical mixture. Keyword: β-cyclodextrin; Physical Mixture; Solvent Evaporation; Taste Masking. INTRODUCTION: The major problem in oral administration of bitter drugs are unacceptability by the patients mainly pediatric and geriatrics [1] and this can be overcome by masking the bitterness of drug either by decreasing its oral Corresponding Author’s Contact information: Soniya Madaan * B.S. Anangpuria College of Pharmacy, Alampur (Faridabad), India E-mail: Soniya.madan21@gmail.com solubility on ingestion or decreasing the interaction of drug particles to taste buds [2] . There are various techniques available which are used for masking the taste of bitter drugs including coating, solid dispersion, ion exchange resin, entrapment method and masking of taste buds etc. Coating avoids the contact of drug particles with taste buds and taste is not apparent to the users [3] . Dispersion of one or more active ingredients in an inert carrier or matrix in solid